{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DEPDC1‐AS1 is a long non‐coding antisense RNA that has recently emerged as an important regulator in various cancer types. Although its mechanistic details remain to be fully elucidated, DEPDC1‐AS1 has been implicated in carcinogenesis by influencing key cellular processes and signaling pathways. Its dysregulated expression has been associated with adverse clinical outcomes. In lung adenocarcinoma, for example, DEPDC1‐AS1 forms part of a prognostic signature where elevated expression correlates with a shorter overall survival and may also indicate poor responsiveness to immunotherapy or anti‐angiogenic treatments."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, DEPDC1‐AS1 has been identified among a panel of ferroptosis‐related lncRNAs used to construct a risk model in lung adenocarcinoma, suggesting its involvement in iron‐dependent cell death pathways that affect tumor cell survival and metabolic remodeling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, integrated transcriptomic analyses in other cancers, such as clear cell renal cell carcinoma, further highlight the cooperative regulatory roles of lncRNAs, including DEPDC1‐AS1, in tumor heterogeneity and progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Additionally, its discovery as a novel lncRNA in carcinogenesis and the availability of dedicated databases such as DecoderNA underscore its potential utility as a prognostic biomarker and a target for therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lingge Yang, Yuan Wu, Huan Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and Validation of a Novel Six-lncRNA-Based Prognostic Model for Lung Adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2021.775583"}], "href": "https://doi.org/10.3389/fonc.2021.775583"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35111670"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35111670"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lu Lu, Le-Ping Liu, Qiang-Qiang Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a Ferroptosis-Related LncRNA Signature as a Novel Prognosis Model for Lung Adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2021.675545"}], "href": "https://doi.org/10.3389/fonc.2021.675545"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34249715"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34249715"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zongcheng Li, Yaowen Chen, Shuofeng Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrative analysis of protein-coding and non-coding RNAs identifies clinically relevant subtypes of clear cell renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.12340"}], "href": "https://doi.org/10.18632/oncotarget.12340"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27705920"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27705920"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Wei Xu, Juan Wang, Jinfu Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "DEPDC1-AS1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " promotes proliferation and migration of human gastric cancer cells HGC-27 via the human antigen R-F11R pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Int Med Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/03000605221093135"}], "href": "https://doi.org/10.1177/03000605221093135"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35466755"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35466755"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Steve Lefever, Jasper Anckaert, Pieter-Jan Volders, et al. "}, {"type": "b", "children": [{"type": "t", "text": "decodeRNA- predicting non-coding RNA functions using guilt-by-association."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Database (Oxford) (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/database/bax042"}], "href": "https://doi.org/10.1093/database/bax042"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29220434"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29220434"}]}]}]}