{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent investigations into the molecular underpinnings of glioma progression have identified DGCR10 as a protective factor with tumor‐suppressive activity. In particular, functional analysis within a panel of mesenchymal subtype–related long non‐coding RNAs revealed that knockdown of DGCR10 significantly enhanced the migration and invasion of glioma cells, suggesting that DGCR10 normally acts to restrain these aggressive cellular behaviors (5). This protective role implies that DGCR10 may help to stabilize cellular architecture and counteract pathways associated with mesenchymal transition—a process that, when dysregulated, contributes to tumor progression. Although studies in other biological contexts, such as the regulation of epithelial‐to‐mesenchymal transition during gastrulation (1) and the refinement of diagnostic strategies using high‐resolution genomic assays (4), underline the importance of precise molecular regulation, the specific mechanisms by which DGCR10 exerts its inhibitory effects in glioma remain to be fully elucidated. Overall, the identification of DGCR10 as a determinant of glioma invasiveness contributes to the growing evidence that distinct regulatory RNAs within mesenchymal signatures serve as valuable prognostic biomarkers and potential therapeutic targets."}]}, {"type": "t", "text": "\n\n "}, {"type": "p", "children": [{"type": "b", "children": [{"type": "t", "text": "Citations:"}]}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yukiko Nakaya, Erike W Sukowati, Guojun Sheng "}, {"type": "b", "children": [{"type": "t", "text": "Epiblast integrity requires CLASP and Dystroglycan-mediated microtubule anchoring to the basal cortex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201302075"}], "href": "https://doi.org/10.1083/jcb.201302075"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23940118"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23940118"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Andrea Bender, Sieghard Beller "}, {"type": "b", "children": [{"type": "t", "text": "Fingers as a tool for counting - naturally fixed or culturally flexible?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Psychol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fpsyg.2011.00256"}], "href": "https://doi.org/10.3389/fpsyg.2011.00256"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22016741"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22016741"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Martin Wagenmann, Jörg Schipper "}, {"type": "b", "children": [{"type": "t", "text": "The transnasal approach to the skull base. 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