| Name | DiGeorge syndrome critical region gene 12 (non-protein coding) |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n A careful review of the three studies shows that none of the abstracts explicitly discuss or investigate the function of DGCR12. Instead, these studies focus on distinct aspects of neuronal development and pathology. One study examines caspase‐mediated neuronal death in an immature model of status epilepticus, highlighting different cell death mechanisms in distinct hippocampal neuronal populations (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Another study maps the spatiotemporal expression of Sonic hedgehog and related transcription factors in the developing rostral forebrain, providing insights into regional patterning (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " The third study details the early differentiation and migration of telencephalic somatostatin‐expressing cells from the subpallium, further defining interneuron origins (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Although DGCR12, known to reside in the DiGeorge syndrome critical region, has been speculated to play a role in neural development, none of the evidence presented in these abstracts directly assigns it a function. As a result, while the broader contexts of neuronal maturation, regional patterning, and interneuron migration are well addressed, the specific contribution or regulatory role of DGCR12 remains undetermined by these studies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Maria-Leonor Lopez-Meraz, Claude G Wasterlain, Luisa L Rocha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vulnerability of postnatal hippocampal neurons to seizures varies regionally with their maturational stage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Dis (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.nbd.2009.10.019"}], "href": "https://doi.org/10.1016/j.nbd.2009.10.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19879360"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19879360"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sylvia M Bardet, José L E Ferran, Luisa Sanchez-Arrones, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ontogenetic expression of sonic hedgehog in the chicken subpallium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Neuroanat (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fnana.2010.00028"}], "href": "https://doi.org/10.3389/fnana.2010.00028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20700498"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20700498"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Luis Puelles, N Morales-Delgado, P Merchán, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Radial and tangential migration of telencephalic somatostatin neurons originated from the mouse diagonal area."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Struct Funct (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00429-015-1086-8"}], "href": "https://doi.org/10.1007/s00429-015-1086-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26189100"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26189100"}]}]}]}
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| Synonyms | DGS-E |
| NCBI Gene ID | 25784 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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DGCR12 has 8 functional associations with biological entities spanning 2 categories (chemical, gene, protein or microRNA) extracted from 3 datasets.
Click the + buttons to view associations for DGCR12 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of DGCR12 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of DGCR12 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of DGCR12 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |