{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DGCR9, a long non‐coding RNA located within the DiGeorge syndrome critical region, has recently been implicated in cancer biology. In one study of hepatitis B virus–positive hepatocellular carcinoma, DGCR9 was identified as part of a nine‐lncRNA prognostic signature associated with disease progression and metabolic regulation, suggesting a regulatory role in tumor development and an impact on patient outcome."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Moreover, proteogenomic analyses have demonstrated that transcripts from non‐coding regions—including DGCR9—can give rise to peptides that are overexpressed in tumor tissues compared to normal controls. These “dark antigens” may serve as novel tumor‐associated markers or immunotherapeutic targets."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings indicate that DGCR9 may contribute to tumor biology through dual mechanisms: as a regulatory RNA influencing tumor progression and metabolism, and as a source of tumor‐specific peptides with potential applications in cancer immunotherapy. Further research is warranted to fully elucidate its molecular functions and clinical applications.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Honghong Liu, Ping Zhao, Xueyuan Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A 9‑lncRNA risk score system for predicting the prognosis of patients with hepatitis B virus‑positive hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2019.10262"}], "href": "https://doi.org/10.3892/mmr.2019.10262"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31115573"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31115573"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Rong Xiang, Leyao Ma, Mingyu Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased expression of peptides from non-coding genes in cancer proteomics datasets suggests potential tumor neoantigens."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Commun Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s42003-021-02007-2"}], "href": "https://doi.org/10.1038/s42003-021-02007-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33888849"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33888849"}]}]}]}