{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Deoxyguanosine kinase antisense RNA 1 (DGUOK‐AS1) is an oncogenic long noncoding RNA that is aberrantly expressed in multiple cancers. In cervical cancer, for example, DGUOK‐AS1 has been shown to promote tumor progression through at least two distinct ceRNA mechanisms. One study demonstrated that DGUOK‐AS1 functions as a molecular sponge for miR‑499a‑5p, thereby releasing SPRR1B and facilitating enhanced cell viability, proliferation, and migration while inhibiting apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In another investigation using cervical cancer models, DGUOK‐AS1 was found to sequester miR‑653‑5p, leading to elevated EMSY expression which is required for increased cell proliferation and impaired DNA damage repair."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, in breast cancer, knockdown of DGUOK‐AS1 significantly suppressed cell proliferation, migration, and invasion, underscoring its role in promoting metastasis and tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Additional studies have also examined the deregulated expression and functional impact of DGUOK‐AS1 in various tumor types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Collectively, these findings reveal that DGUOK‐AS1 acts as a competing endogenous RNA that disrupts miRNA-mediated regulation of key oncogenes, thereby contributing to cancer cell proliferation, migration, invasion, and survival.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yan Song, Hongjuan Pan, Ling Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DGUOK-AS1 promotes cervical squamous cell carcinoma progression by suppressing miR-499a-5p that targets SPRR1B in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2021.11.003"}], "href": "https://doi.org/10.1016/j.bbrc.2021.11.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34808501"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34808501"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Nanchang Wu, Honglin Song, Yaoyao Ren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DGUOK-AS1 promotes cell proliferation in cervical cancer via acting as a ceRNA of miR-653-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biochem Funct (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cbf.3506"}], "href": "https://doi.org/10.1002/cbf.3506"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32283566"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32283566"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yiran Liang, Fangzhou Ye, Yajie Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DGUOK-AS1 acts as a tumorpromoter through regulatingmiR-204-5p/IL-11 axis in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Ther Nucleic Acids (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.omtn.2021.10.018"}], "href": "https://doi.org/10.1016/j.omtn.2021.10.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34786212"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34786212"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Unknown Authors "}, {"type": "b", "children": [{"type": "t", "text": "Statement of Retraction: DGUOK-AS1 promotes the proliferation cervical cancer through regulating miR-653-5p/EMSY."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biol Ther (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384047.2021.1926124"}], "href": "https://doi.org/10.1080/15384047.2021.1926124"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34182893"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34182893"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yalun Li, Yiran Liang, Tingting Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of DGUOK-AS1 as a Prognostic Factor in Breast Cancer by Bioinformatics Analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2020.01092"}], "href": "https://doi.org/10.3389/fonc.2020.01092"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32766141"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32766141"}]}]}]}