{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DICER1‐AS1 is a long non‐coding RNA with context‐dependent functions in human diseases that modulate cellular proliferation, migration, autophagy, metabolism, and stress responses. In osteosarcoma, multiple studies have demonstrated that DICER1‐AS1 is upregulated, where its increased expression correlates with advanced clinical stage, distant metastasis, and poor prognosis. Functionally, DICER1‐AS1 appears to promote osteosarcoma cell proliferation, invasion, and autophagy through mechanisms involving miRNA sponging (e.g., sequestering miR‐30b to impact ATG5 levels) and epigenetic modulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In contrast, in pancreatic cancer DICER1‐AS1 is downregulated, and its forced overexpression attenuates glycolysis, cell proliferation, and metastasis by recruiting transcription factor YY1 to the DICER1 promoter. This upregulates DICER1 expression and enhances miR‐5586–5p maturation, which in turn downregulates key glycolytic genes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Similarly, in colorectal cancer, elevated DICER1‐AS1 functions as an oncogenic factor by sponging miR‐296–5p to relieve suppression of STAT3, thereby promoting malignant progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Diverse expression patterns are also noted in other clinical settings. In gastric cancer and in coronary artery disease, DICER1‐AS1 expression is reduced, suggesting potential diagnostic utility in non‐tumoral contexts."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "8"}]}, {"type": "t", "text": " In breast cancer, metformin treatment leads to an upregulation of DICER1‐AS1, implicating its involvement in epigenetic regulatory networks, while its inclusion in risk prediction signatures for ovarian and colorectal cancers underscores its potential prognostic significance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "12"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, environmental stressors such as arsenic can downregulate DICER1‐AS1, leading to cell cycle arrest and reduced proliferation in lung adenocarcinoma cells"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": ", and increased expression in the peripheral blood of schizophrenia patients suggests a broader role in neuroinflammatory or neurodevelopmental processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings indicate that DICER1‐AS1 exerts multifaceted regulatory functions via mechanisms such as miRNA sponging, modulation of autophagy, and metabolic reprogramming. Its divergent roles across various disease contexts highlight the promise of DICER1‐AS1 as both a diagnostic biomarker and a potential therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "X-H Hu, J Dai, H-L Shang, et al. 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