{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent genome‐wide association studies have begun to shed light on the potential regulatory roles of noncoding RNAs in complex vascular diseases, including ischemic stroke. In this context, DIO2‑AS1—a long noncoding antisense transcript related to the DIO2 gene—has emerged as a candidate molecule of interest. Although the detailed molecular mechanism of DIO2‑AS1 remains to be fully elucidated, available evidence suggests that it may function in cis to modulate the expression of nearby protein‐coding genes involved in crucial cellular processes, such as autophagy and metabolic regulation. For instance, one study identified genetic variations in a related pathway—via SNP clusters in key autophagy‐related genes (e.g., ATG7)—which underscores the growing recognition that regulatory noncoding RNAs like DIO2‑AS1 might influence pathways that determine vascular homeostasis and neuronal survival in ischemic conditions (1). This emerging insight points to DIO2‑AS1 as a promising target for further studies investigating its contribution to stroke susceptibility and its potential as a biomarker or therapeutic target.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n (1)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tsong-Hai Lee, Tai-Ming Ko, Chien-Hsiun Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A genome-wide association study links small-vessel ischemic stroke to autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-017-14355-3"}], "href": "https://doi.org/10.1038/s41598-017-14355-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29123153"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29123153"}]}]}]}