{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DIPK1A appears to be a member of a novel family of cysteine‐rich, type II transmembrane proteins that localize predominantly to the endoplasmic reticulum and are predicted to function as protein kinases. Structural analyses indicate that these proteins harbor a conserved kinase domain—with some members containing an inserted EF‐hand Ca²⁺–binding motif—suggesting that they may operate as Ca²⁺–dependent kinases that phosphorylate substrates within the secretory pathway. In addition to their ubiquitous expression, differential levels of DIPK1A (often interchanged with the FAM69A designation in several studies) have been noted in diverse biological contexts. For example, altered expression has been implicated in neuroimmunological conditions such as myasthenia gravis, which hints at a role in modulating neuromuscular as well as immune‐related signaling events, while reduced expression levels have also been associated with colorectal tumor progression, underscoring a potential involvement in cancer prognosis. Collectively, these observations support the hypothesis that DIPK1A is an evolutionarily conserved kinase whose catalytic activity in the ER and secretory compartments may influence a range of cellular processes—from intracellular signal transduction and secretory protein regulation to the control of gene expression and cell differentiation—that become perturbed in complex disorders."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Anthea J Tennant-Eyles, Hilary Moffitt, Caroline A Whitehouse, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterisation of the FAM69 family of cysteine-rich endoplasmic reticulum proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2011.02.076"}], "href": "https://doi.org/10.1016/j.bbrc.2011.02.076"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21334309"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21334309"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Małgorzata Dudkiewicz, Anna Lenart, Krzysztof Pawłowski "}, {"type": "b", "children": [{"type": "t", "text": "A novel predicted calcium-regulated kinase family implicated in neurological disorders."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0066427"}], "href": "https://doi.org/10.1371/journal.pone.0066427"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23840464"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23840464"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Melissa Nel, Sharon Prince, Jeannine M Heckmann "}, {"type": "b", "children": [{"type": "t", "text": "Profiling of patient-specific myocytes identifies altered gene expression in the ophthalmoplegic subphenotype of myasthenia gravis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Orphanet J Rare Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13023-019-1003-y"}], "href": "https://doi.org/10.1186/s13023-019-1003-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30696470"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30696470"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Chunhui Jiang, Ye Liu, Siyuan Wen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "In silico development and clinical validation of novel 8 gene signature based on lipid metabolism related genes in colon adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacol Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.phrs.2021.105644"}], "href": "https://doi.org/10.1016/j.phrs.2021.105644"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33940186"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33940186"}]}]}]}