{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DIPK1C appears to belong to a conserved family of cysteine‐rich, type II transmembrane proteins that harbor a predicted protein kinase domain. Structural analyses indicate that these proteins retain the classical catalytic motifs essential for phosphotransferase activity, and in some family members an integrated EF‐hand Ca²⁺–binding module suggests calcium‐dependent regulation. In mammalian systems, the DIPK1C orthologue localizes predominantly to the endoplasmic reticulum, implying a role in the phosphorylation of substrates within the secretory pathway and/or extracellular proteins. Expression data further indicate that DIPK1C is enriched in the central nervous system (notably in brain and eye tissues), suggesting specialized functions in neuronal cell biology that might underpin its association with neurological phenotypes. The evolutionary conservation of its structure across metazoans points to a fundamental role in maintaining ER homeostasis and regulating protein processing. Although not yet fully characterized, DIPK1C is emerging as a candidate mediator linking intracellular signaling with neuronal and secretory pathway functions, thereby contributing to both basal cellular homeostasis and specialized tissue-specific roles."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Małgorzata Dudkiewicz, Anna Lenart, Krzysztof Pawłowski "}, {"type": "b", "children": [{"type": "t", "text": "A novel predicted calcium-regulated kinase family implicated in neurological disorders."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0066427"}], "href": "https://doi.org/10.1371/journal.pone.0066427"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23840464"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23840464"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Anthea J Tennant-Eyles, Hilary Moffitt, Caroline A Whitehouse, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterisation of the FAM69 family of cysteine-rich endoplasmic reticulum proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2011.02.076"}], "href": "https://doi.org/10.1016/j.bbrc.2011.02.076"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21334309"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21334309"}]}]}]}