{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DLEU7‐AS1, a long non‐coding RNA, has recently emerged as a biomarker with diverse functions across cancer types. In acute myeloid leukemia (AML), expression analysis revealed that overall levels of DLEU7‐AS1 are markedly reduced compared with normal bone marrow; however, among AML patients, relatively higher DLEU7‐AS1 expression is associated with lower complete remission rates and shorter overall survival, suggesting that its upregulation in this context may reflect a more aggressive disease course."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, studies in colorectal cancer (CRC) demonstrate that DLEU7‐AS1 is significantly overexpressed in tumor tissues relative to adjacent normal tissues. Elevated DLEU7‐AS1 levels in CRC are correlated with advanced tumor stage, increased lymph node and distant metastases, and poorer patient prognosis. Functional experiments further indicate that DLEU7‐AS1 promotes proliferation, invasion, and migration of CRC cells, at least in part by modulating the Wnt/β‐catenin signaling pathway, as evidenced by the concomitant downregulation of key pathway proteins upon its silencing."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Additionally, in gastric cancer, DLEU7‐AS1 is featured as part of a competing endogenous RNA network, where its strong diagnostic potential (reflected by a high area under the curve in receiver operating characteristic analysis) highlights its promise as a novel biomarker for cancer detection and potentially for guiding therapeutic interventions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Cui-Zhu Wang, Bei-Bei Ma, Zi-Jun Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reduced expression of lncRNA DLEU7-AS1 is a novel favorable prognostic factor in acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20212078"}], "href": "https://doi.org/10.1042/BSR20212078"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35506368"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35506368"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "X-B Liu, C Han, C-Z Sun "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA DLEU7-AS1 promotes the occurrence and development of colorectal cancer via Wnt/β-catenin pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201801_14107"}], "href": "https://doi.org/10.26355/eurrev_201801_14107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29364477"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29364477"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yuyou Jiang, Xianqin Zhang, Li Rong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrative analysis of the gastric cancer long non-coding RNA-associated competing endogenous RNA network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Lett (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ol.2021.12717"}], "href": "https://doi.org/10.3892/ol.2021.12717"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33907566"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33907566"}]}]}]}