{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DLG1‐AS1 is emerging as an important oncogenic long non‐coding RNA in multiple solid tumors. In cervical cancer, DLG1‐AS1 is highly upregulated and contributes to tumor progression by sponging miR‑107, thereby releasing the inhibition on its target gene ZHX1 and promoting cell proliferation and poor prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In papillary thyroid carcinoma, elevated plasma and tissue levels of DLG1‑AS1 are associated with advanced tumor stage and lymph node metastasis; mechanistically, DLG1‑AS1 downregulates miR‑199a‑3p, leading to increased cell proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In the context of chemoresistance, particularly in gemcitabine‐resistant cervical cancer, DLG1‑AS1 promotes cell viability and proliferation by targeting the miR‑16‑5p/hepatoma‐derived growth factor (HDGF) axis, thereby reducing drug sensitivity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Moreover, in hepatocellular carcinoma, DLG1‑AS1 is transcriptionally activated by MYC and acts as a molecular sponge for miR‑497‑5p, resulting in enhanced expression of SSRP1 and the promotion of tumor cell growth and migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In triple‐negative breast cancer, DLG1‑AS1 is similarly upregulated and exerts its oncogenic effects by downregulating the tumor suppressor miR‑203, which in turn facilitates cell proliferation and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In addition, network analyses in glioblastoma have identified DLG1‑AS1 as a hub within the competing endogenous RNA (ceRNA) regulatory circuitry, further outlining its critical role in tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaohui Rui, Yun Xu, Yaqing Huang, et al. 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