{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DLG2‐AS1 is a long non‐coding RNA transcribed in an antisense direction relative to the DLG2 gene that has been implicated in two distinct disease settings. In lung adenocarcinoma, DLG2‐AS1 expression was found to be consistently downregulated in tumor samples compared to adjacent normal tissues, and although its re‐expression in cancer cell lines did not alter the protein levels of its overlapping gene DLG2, its differential expression profile confers high sensitivity and specificity as a potential diagnostic biomarker for the disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In a separate study focused on schizophrenia, a related antisense transcript (designated PSZA11q14) was identified within the first intron of the DLG2 gene; its reduced expression in patient brains and genomic location suggest that it may function as an antisense regulator of DLG2 and thereby influence processes such as the assembly of functional N‐methyl‐D‐aspartate receptors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Collectively, these findings underscore a multifaceted role for DLG2‐AS1 in human disease, serving both as a promising biomarker in lung cancer and as a candidate regulatory molecule that might contribute to synaptic dysfunction in neuropsychiatric disorders.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Alberto M Arenas, Marta Cuadros, Alvaro Andrades, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA DLG2-AS1 as a Novel Biomarker in Lung Adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancers (Basel) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cancers12082080"}], "href": "https://doi.org/10.3390/cancers12082080"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32731343"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32731343"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Oxana O Polesskaya, Vahram Haroutunian, Kenneth L Davis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel putative nonprotein-coding RNA gene from 11q14 displays decreased expression in brains of patients with schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci Res (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jnr.10752"}], "href": "https://doi.org/10.1002/jnr.10752"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "13130513"}], "href": "https://pubmed.ncbi.nlm.nih.gov/13130513"}]}]}]}