{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DLG5‐AS1 is a long non‐coding RNA that has been implicated in cancer progression and prognostication. In a pan‐cancer analysis of nearly 6,000 tumors, driver lncRNAs with genomic properties comparable to known cancer driver genes were identified. Among these, lncRNAs involved in tissue invasion and metastasis were validated in cancers such as lung adenocarcinoma and breast cancer, indicating that DLG5‐AS1 may contribute to tumor invasion and metastatic dissemination."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " \n Furthermore, in an independent study focusing on prostate cancer, an integrative prognostic signature combining lncRNAs and mRNAs was developed. DLG5‐AS1 was one of the lncRNAs incorporated into this nine‐gene signature that correlated with overall survival, suggesting its potential role as a prognostic biomarker for stratification of high‐risk patients."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yulan Deng, Shangyi Luo, Xinxin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A pan-cancer atlas of cancer hallmark-associated candidate driver lncRNAs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1878-0261.12381"}], "href": "https://doi.org/10.1002/1878-0261.12381"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30216655"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30216655"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jiarong Cai, Zheng Chen, Xuelian Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Coexpression Network Analysis Identifies a Novel Nine-RNA Signature to Improve Prognostic Prediction for Prostate Cancer Patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/4264291"}], "href": "https://doi.org/10.1155/2020/4264291"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32953881"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32953881"}]}]}]}