{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DLGAP4‐AS1 is a long noncoding RNA (lncRNA) with the general features and functions attributed to this class of transcripts. As highlighted in the colorectal cancer context (see"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", lncRNAs such as DLGAP4‐AS1 do not encode proteins but instead modulate cellular processes by interacting with DNA, RNA, and proteins. These interactions can affect transcriptional regulation, post‐transcriptional modifications, and ultimately cellular phenotypes, which in the case of cancers, contribute to tumor biology. Notably, in colorectal cancer research, lncRNAs have been emphasized as promising biomarkers due to their cancer‐specific expression profiles."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In a similar vein, investigations into endometrial cancer through comprehensive germline variant analyses (see"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "underscore the emerging interest in noncoding regions—including lncRNAs—as potential contributors to hereditary cancer risk. Although DLGAP4‐AS1 is not explicitly detailed in the endometrial cancer study, its categorization as a lncRNA implies that genetic alterations or expression changes in such transcripts may have clinical significance in cancer predisposition and progression.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, DLGAP4‐AS1 is a functionally versatile lncRNA that likely contributes to tumorigenesis by regulating gene expression through its interactions with multiple cellular molecules, thus presenting potential value as a diagnostic or prognostic biomarker in cancers such as colorectal and endometrial cancer (1,2).\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Taewan Kim, Carlo M Croce "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNAs: Undeciphered cellular codes encrypting keys of colorectal cancer pathogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2017.12.033"}], "href": "https://doi.org/10.1016/j.canlet.2017.12.033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29306015"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29306015"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Manu Shivakumar, Jason E Miller, Venkata Ramesh Dasari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exome-Wide Rare Variant Analysis From the DiscovEHR Study Identifies Novel Candidate Predisposition Genes for Endometrial Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2019.00574"}], "href": "https://doi.org/10.3389/fonc.2019.00574"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31338326"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31338326"}]}]}]}