{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DLX2‑AS1 is a long noncoding RNA that has been implicated in the prognosis and regulation of cellular stress responses in diverse pathological settings. In hepatocellular carcinoma, DLX2‑AS1 was identified as one of five differentially expressed lncRNAs used to construct a prognostic risk‐assessment model, with its altered expression correlating with patient survival outcomes (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, studies in periodontal ligament cells demonstrated that DLX2‑AS1 expression is suppressed following lipopolysaccharide stimulation. Overexpression of DLX2‑AS1 in these cells led to a reduction in inflammatory cytokine production and decreased apoptosis. Mechanistically, DLX2‑AS1 functions by sponging microRNA‑330‑3p, thereby regulating the expression of its target, RO60, which ultimately moderates the inflammatory response and apoptosis in these cells (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yongqiang Sun, Fangfang Zhang, Lifu Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A five lncRNA signature for prognosis prediction in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2019.10203"}], "href": "https://doi.org/10.3892/mmr.2019.10203"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31059056"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31059056"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhihua Wang, Dazhao Wang, Song Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA distal-less homeobox 2 antisense 1 restrains inflammatory response and apoptosis of periodontal ligament cells by binding with microRNA-330-3p to regulate Ro60, Y RNA binding protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Oral Biol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.archoralbio.2021.105298"}], "href": "https://doi.org/10.1016/j.archoralbio.2021.105298"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34752991"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34752991"}]}]}]}