{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent gene‐editing and proteomic studies have identified DMAC1 as a critical accessory factor in the biogenesis of mitochondrial Complex I, the largest multi‐subunit enzyme of the respiratory chain. Specifically, DMAC1 is required for the proper assembly of the distal portion of the Complex I membrane arm, functioning in concert with other assembly factors (e.g., ATP5SL) to promote the integration and stability of subunits necessary for efficient electron transport and ATP production. Loss of DMAC1 disrupts the assembly process, thereby potentially compromising oxidative phosphorylation and overall cellular energy homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "David A Stroud, Elliot E Surgenor, Luke E Formosa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Accessory subunits are integral for assembly and function of human mitochondrial complex I."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature19754"}], "href": "https://doi.org/10.1038/nature19754"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27626371"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27626371"}]}]}]}