{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Mitochondrial function relies on both dynamic structural remodeling and the precise assembly of its oxidative phosphorylation complexes. In this context, a growing body of research has underscored the importance of accessory factors in governing the assembly and stability of these large multimeric protein machines."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " Recent gene‐editing coupled with quantitative proteomic analyses has revealed that proteins belonging to the DMAC family play a critical role in the assembly of complex I of the mitochondrial respiratory chain. In particular, the study demonstrated that loss of a DMAC family member—here referenced as DMAC1 (which, in the context of our query, appears analogous to DMAC2)—disrupts the incorporation of subunits into the distal portion of the membrane arm. This disruption can compromise the overall integrity of complex I, potentially affecting efficient electron transfer and ATP synthesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Thus, by facilitating the proper assembly of key structural modules in complex I, DMAC2 (or the DMAC1/2 family) emerges as an essential regulatory node in mitochondrial bioenergetics. This insight not only enhances our understanding of mitochondrial complex biogenesis but also suggests that perturbations in DMAC2 function may underlie defects in energy metabolism, which are relevant to various human pathologies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Filipe Carvalho, Anna Spier, Thibault Chaze, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Listeria monocytogenes Exploits Mitochondrial Contact Site and Cristae Organizing System Complex Subunit Mic10 To Promote Mitochondrial Fragmentation and Cellular Infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "mBio (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/mBio.03171-19"}], "href": "https://doi.org/10.1128/mBio.03171-19"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32019800"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32019800"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Grigory I Belogrudov "}, {"type": "b", "children": [{"type": "t", "text": "Recent advances in structure-functional studies of mitochondrial factor B."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bioenerg Biomembr (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10863-009-9210-1"}], "href": "https://doi.org/10.1007/s10863-009-9210-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19377834"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19377834"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Alba Signes, Erika Fernandez-Vizarra "}, {"type": "b", "children": [{"type": "t", "text": "Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Essays Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/EBC20170098"}], "href": "https://doi.org/10.1042/EBC20170098"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30030361"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30030361"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "David A Stroud, Elliot E Surgenor, Luke E Formosa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Accessory subunits are integral for assembly and function of human mitochondrial complex I."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature19754"}], "href": "https://doi.org/10.1038/nature19754"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27626371"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27626371"}]}]}]}