{"type": "root", "children": [{"type": "t", "text": "<head>\n <meta charset=\"UTF-8\">\n <title>DMRTC1B Function Summary</title>\n </head>\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Although none of the three abstracts explicitly detail the molecular role of DMRTC1B, clues about its likely function can be deduced from the context in which it was identified. In the study focusing on the Sertoli cell transcriptome (1), a wide array of Sertoli‐specific transcripts was characterized, with many of these being regulated by follicle‐stimulating hormone (FSH) and androgens. Given that DMRTC1B is included among transcripts related to testicular development, it is reasonable to infer that DMRTC1B may function as a transcriptional regulator that contributes to the differentiation and maintenance of Sertoli cell function. In this role, DMRTC1B would be part of the gene network under hormonal control that drives testis development and the maturation of tissue-specific processes."}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In a broader context, other abstracts in the collection examine sex‐dependent gene expression in peripheral tissues (2) and gene expression changes in pain models (3). Although these studies do not directly address DMRTC1B, their focus on sexually dimorphic gene regulation further suggests that factors involved in sex‐specific developmental programs—such as members of the DMRT gene family to which DMRTC1B likely belongs—may play important roles in establishing and maintaining differences in physiology across tissues.\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, DMRTC1B appears to be a gene whose expression in Sertoli cells is subject to hormonal regulation, implying a role in testis differentiation and development. Further targeted studies will be required to elucidate its precise molecular function and to determine whether it has additional roles in broader sex‐specific physiological processes.\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n References:."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "U Soffientini, D Rebourcet, M H Abel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Sertoli cell-specific transcripts in the mouse testis and the role of FSH and androgen in the control of Sertoli cell activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Genomics (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12864-017-4357-3"}], "href": "https://doi.org/10.1186/s12864-017-4357-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29246116"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29246116"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Pradipta R Ray, Jawad Khan, Andi Wangzhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptome Analysis of the Human Tibial Nerve Identifies Sexually Dimorphic Expression of Genes Involved in Pain, Inflammation, and Neuro-Immunity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Mol Neurosci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fnmol.2019.00037"}], "href": "https://doi.org/10.3389/fnmol.2019.00037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30890918"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30890918"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hyeonsoo Jeong, Laura S Moye, Bruce R Southey, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene Network Dysregulation in the Trigeminal Ganglia and Nucleus Accumbens of a Model of Chronic Migraine-Associated Hyperalgesia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Syst Neurosci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fnsys.2018.00063"}], "href": "https://doi.org/10.3389/fnsys.2018.00063"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30618656"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30618656"}]}]}]}