{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DNAH17‐AS1 is an oncogenic long noncoding RNA that is aberrantly overexpressed in several cancers, including pancreatic carcinoma, non‐small cell lung cancer (NSCLC), and colorectal cancer. In pancreatic carcinoma, DNAH17‐AS1 acts as a competing endogenous RNA that sponges miR‑432‑5p, thereby de‐repressing its target PPME1; this regulation promotes cell viability, invasion, and migration while inhibiting apoptosis, ultimately contributing to aggressive tumor behavior and poor patient prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in NSCLC, DNAH17‑AS1 functions as a molecular sponge for miR‑877‑5p, leading to upregulation of CCNA2 and enhanced proliferation, migration, and invasion, which correlate with advanced TNM stage, distant metastasis, and reduced overall and disease‑free survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In colorectal cancer, elevated levels of DNAH17‑AS1 have been identified as an independent prognostic factor; co‑expression network analyses link DNAH17‑AS1 to protein‑coding genes involved in G‑protein coupled receptor–related functions, suggesting its participation in key signaling pathways that drive tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Furthermore, while comprehensive lncRNA profiling in pancreatic cancer has yielded prognostic signatures implicating lncRNAs in tumor immune responses"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", the collective evidence underscores the pivotal role of DNAH17‑AS1 as an oncogenic regulator and highlights its potential as a promising therapeutic target across multiple tumor types.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tao Xu, Ting Lei, Si-Qiao Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNAH17-AS1 promotes pancreatic carcinoma by increasing PPME1 expression "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "via"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " inhibition of miR-432-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Gastroenterol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3748/wjg.v26.i15.1745"}], "href": "https://doi.org/10.3748/wjg.v26.i15.1745"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32351291"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32351291"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Li-Juan Du, Long-Jun Mao, Rui-Jun Jing "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA DNAH17-AS1 promotes tumorigenesis and metastasis of non-small cell lung cancer via regulating miR-877-5p/CCNA2 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2020.09.047"}], "href": "https://doi.org/10.1016/j.bbrc.2020.09.047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32981678"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32981678"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wen Zhou, Boyu Pan, Liren Liu "}, {"type": "b", "children": [{"type": "t", "text": "Integrated bioinformatics analysis revealing independent prognostic long non-coding RNAs DNAH17-AS1 and RP11-400N13.2 and their potential oncogenic roles in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Lett (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ol.2019.10730"}], "href": "https://doi.org/10.3892/ol.2019.10730"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31516583"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31516583"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Bin Wu, Kaixuan Wang, Janguo Fei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel three‑lncRNA signature predicts survival in patients with pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2018.6761"}], "href": "https://doi.org/10.3892/or.2018.6761"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30542694"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30542694"}]}]}]}