{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DNAJB4 (also known as HLJ1) is a member of the Hsp40 (DnaJ) family that plays a key role in suppressing tumor progression by modulating protein quality control and cell–cell adhesion. Multiple studies have demonstrated that increased DNAJB4 expression inhibits cancer cell invasion, migration, and metastasis in lung, colorectal, gastric, and melanoma tumors by promoting the stabilization of E‐cadherin and down‐regulating matrix metalloproteinases, thereby reinforcing epithelial characteristics and limiting epithelial–mesenchymal transition (EMT) (see, for example"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ", and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In lung adenocarcinoma and colorectal carcinoma, restoration or up‐regulation of DNAJB4 inhibits tumor cell proliferation and motility via mechanisms involving enhancement of E‐cadherin expression and activation of anti‐invasive pathways, which correlates clinically with reduced recurrence and improved overall survival"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In gastric cancer, DNAJB4 acts post‐translationally by directly interacting with E‐cadherin to stabilize its plasma membrane localization while favoring the degradation of misfolded mutants, thereby supporting adhesion and counteracting invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Conversely, in mesenchymal breast cancer cells, induction of DNAJB4 during EMT appears to support the migratory phenotype, as its suppression leads to reduced cell migration"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ", and in HBV-related hepatocellular carcinoma, HBV-induced upregulation of DNAJB4 via YY1 has been implicated in tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Finally, proteomic profiling in melanoma revealed that lower DNAJB4 levels are associated with enhanced metastatic potential and poor prognosis, further underlining its role as a metastasis suppressor."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Collectively, these findings indicate that DNAJB4 is an important regulator of proteostasis and cell adhesion whose context-dependent modulation can impact tumor growth and metastasis, making it a promising prognostic marker and therapeutic target in cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Huei-Wen Chen, Jen-Yi Lee, Ji-Ying Huang, et al. 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