{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The long noncoding RNA DNAJC3‐AS1 has emerged as an important oncogenic regulator in multiple cancer types. In osteosarcoma, its up‐regulation is associated with advanced clinical stage and increased differentiation, promoting cell proliferation, migration, invasion, and reduced cisplatin sensitivity via modulation of its sense‐cognate gene DNAJC3."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In clear cell renal cell carcinoma, DNAJC3‐AS1 functions as an oncogene by sponging miR‑27a‑3p, which in turn affects PRDM14 expression and enhances tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In breast cancer, the lncRNA is directly targeted by miR‑144; its overexpression counteracts miR‑144–mediated apoptosis and inhibition of autophagy, thereby contributing to doxorubicin resistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In acute myeloid leukemia, elevated DNAJC3‐AS1 levels interact directly with miR‑140, diminishing miR‑140’s suppressive effects on cell proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In hepatocellular carcinoma, DNAJC3‐AS1 promotes tumor progression by binding premature miR‑27b, impairing its maturation and subsequently enhancing cell proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Finally, in colorectal and colon cancers, overexpression of DNAJC3‐AS1 correlates with poor prognosis by regulating key molecules; in colorectal cancer it modulates fatty acid synthase to drive proliferation, while in colon cancer, it acts as a sponge for miR‑214‑3p to regulate LIVIN expression and activate the NF‑κB pathway, thereby stimulating epithelial–mesenchymal transition, invasion, and tumor growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ridong Liang, Zezheng Liu, Zhixu Chen, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "MiR-140 Targets lncRNA DNAJC3-AS1 to Suppress Cell Proliferation in Acute Myeloid Leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mediterr J Hematol Infect Dis (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4084/MJHID.2022.005"}], "href": "https://doi.org/10.4084/MJHID.2022.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35070212"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35070212"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Changbo Fu, Jianxiu Li, Ping Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA DNAJC3-AS1 Promotes Hepatocellular Carcinoma (HCC) Progression via Sponging Premature miR-27b."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Manag Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/CMAR.S321111"}], "href": "https://doi.org/10.2147/CMAR.S321111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34815712"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34815712"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yanyan Tang, Rui Tang, Mengtian Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA DNAJC3-AS1 Regulates Fatty Acid Synthase "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "via"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " the EGFR Pathway to Promote the Progression of Colorectal Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2020.604534"}], "href": "https://doi.org/10.3389/fonc.2020.604534"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33604287"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33604287"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Bing Han, Yang Ge, Junpeng Cui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulation of lncRNA DNAJC3-AS1 inhibits colon cancer via regulating miR-214-3p/LIVIN axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2020.1757224"}], "href": "https://doi.org/10.1080/21655979.2020.1757224"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32352854"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32352854"}]}]}]}