{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations have identified the long noncoding RNA DNAJC3-AS1 as a key regulator in tumor biology. In clear cell renal cell carcinoma (ccRCC), DNAJC3-AS1 exhibits elevated expression and is implicated in promoting the malignant progression of this common urological cancer by contributing to its aggressive phenotype and poor prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nDis primis duis mauris potenti non at sociosqu ultricies massa. Tincidunt vel sagittis quam convallis varius phasellus tincidunt. In breast cancer, particularly in doxorubicin-resistant MCF-7 cells, DNAJC3-AS1 is directly targeted by miR-144. Restoration of miR-144 levels enhances chemosensitivity, increases apoptosis, and inhibits autophagy, while overexpression of DNAJC3-AS1 counteracts these effects—suggesting that this lncRNA plays a pivotal role in mediating drug resistance by modulating autophagy-related pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n \nFusce class lectus fringilla commodo sit blandit pellentesque. In papillary thyroid carcinoma (PTC), DNAJC3-AS1 is significantly upregulated and functions as a competitive endogenous RNA. It sponges miR-27a-3p, thereby alleviating its inhibitory effect on CCBE1 expression. This axis facilitates tumor development by enhancing cellular malignant behaviors, marking DNAJC3-AS1 as a potential therapeutic target in PTC treatment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "X-Y Na, X-Q Hu, Y Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA DNAJC3-AS1 functions as oncogene in renal cell carcinoma via regulation of the miR-27a-3p/PRDM14 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202102_24833"}], "href": "https://doi.org/10.26355/eurrev_202102_24833"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33629299"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33629299"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ruiping Ren, Zuguo Yuan, Zhengyang Xu "}, {"type": "b", "children": [{"type": "t", "text": "miRNA-144 targeting DNAJC3-AS1 reverses the resistance of the breast cancer cell line Michigan Cancer Foundation-7 to doxorubicin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1999373"}], "href": "https://doi.org/10.1080/21655979.2021.1999373"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34895046"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34895046"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Tiangen Ni, Yongyong Li, Dan Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA DNAJC3-AS1 promotes the biological functions of papillary thyroid carcinoma via regulating the microRNA-27a-3p/CCBE1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Int (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cbin.11946"}], "href": "https://doi.org/10.1002/cbin.11946"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36583660"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36583660"}]}]}]}