{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe provided abstracts do not contain any mention or experimental data regarding DOCK4‐AS1. Each abstract focuses on separate molecular factors in distinct biological systems, and none describe a role for DOCK4‐AS1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFor example, one study evaluated the impact of aerobic exercise on the stress-related proteins Sestrin 1 and Sestrin 2 in skeletal muscle, thereby delineating their relevance in aging‐related metabolic regulation. However, no aspect of DOCK4‐AS1 was explored in this context."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn another investigation, the gene Scrn1 was examined for its role in male fertility, establishing its expression during gonadal sex determination and in Sertoli cells. Yet again, DOCK4‐AS1 is not implicated or mentioned in this genetic analysis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA separate study addressed the function of Galectin-1 in neuronal regeneration, including its interaction with the axonal guidance molecule Secernin-1 as a means to facilitate axonal growth and recovery of memory function in an Alzheimer’s disease model. This work also does not provide any insight into DOCK4‐AS1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, while each study contributes to our understanding of molecular processes in aging, reproductive biology, and neuronal repair, none of the abstracts offer any information regarding the function or relevance of DOCK4‐AS1. Any assignment of function to DOCK4‐AS1 would require additional literature that specifically investigates this long noncoding RNA.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Barbara M Crisol, Luciene Lenhare, Rodrigo S Gaspar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of physical exercise on Sestrin1 and 2 accumulations in the skeletal muscle of mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lfs.2017.12.023"}], "href": "https://doi.org/10.1016/j.lfs.2017.12.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29273527"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29273527"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Brendan J Houston, Liina Nagirnaja, D Jo Merriner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Sertoli cell expressed gene secernin-1 (Scrn1) is dispensable for male fertility in the mouse."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Dyn (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/dvdy.299"}], "href": "https://doi.org/10.1002/dvdy.299"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33442887"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33442887"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ximeng Yang, Chihiro Tohda "}, {"type": "b", "children": [{"type": "t", "text": "Axonal Regeneration Mediated by a Novel Axonal Guidance Pair, Galectin-1 and Secernin-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Neurobiol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12035-022-03125-6"}], "href": "https://doi.org/10.1007/s12035-022-03125-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36437381"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36437381"}]}]}]}