{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DOCK9 antisense RNA2 (DOCK9‐AS2) is a long non‐coding RNA that plays diverse roles in disease progression. In papillary thyroid carcinoma, for instance, DOCK9‐AS2 is enriched in plasma exosomes and is actively transferred from cancer stem cells, where it promotes tumor aggressiveness by enhancing proliferation, migration, invasion, epithelial‐to‐mesenchymal transition, and stemness. Mechanistically, DOCK9‐AS2 activates the Wnt/β‐catenin pathway by interacting with the transcription factor SP1 to upregulate CTNNB1 transcription, and by sponging microRNA‐1972, both of which contribute to oncogenic signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, DOCK9‐AS2 has emerged in genome‐wide analyses as part of lncRNA expression signatures with prognostic potential in malignancies such as endometrial carcinoma, underscoring its relevance as a potential biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond cancer, bioinformatics studies of atherosclerosis have identified DOCK9‐AS2 as one of several key lncRNAs implicated in processes such as leukotriene biosynthesis, actin filament organization, antigen processing, and interferon‐gamma–mediated signaling pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Experimental studies further suggest that in vascular smooth muscle cells exposed to oxidized low‐density lipoprotein, DOCK9‐AS2 may modulate cellular proliferation and migration, thereby contributing to the disease’s pathophysiology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings highlight DOCK9‐AS2 as a multifunctional lncRNA with important roles in both tumor progression and atherosclerosis, making it a promising candidate for further investigation as a diagnostic and therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wencheng Dai, Xiaoxia Jin, Liang Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal lncRNA DOCK9-AS2 derived from cancer stem cell-like cells activated Wnt/β-catenin pathway to aggravate stemness, proliferation, migration, and invasion in papillary thyroid carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-02827-w"}], "href": "https://doi.org/10.1038/s41419-020-02827-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32917852"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32917852"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Meng Zhou, Zhaoyue Zhang, Hengqiang Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel lncRNA-focus expression signature for survival prediction in endometrial carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-017-3983-0"}], "href": "https://doi.org/10.1186/s12885-017-3983-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29304762"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29304762"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Chuan-Hui Wang, Hui-Hua Shi, Lin-Hui Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Key lncRNAs Associated With Atherosclerosis Progression Based on Public Datasets."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2019.00123"}], "href": "https://doi.org/10.3389/fgene.2019.00123"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30873207"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30873207"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jiachong Shi, Bo Zhou, Zhi Tian "}, {"type": "b", "children": [{"type": "t", "text": "DOCK9 antisense RNA2 interacts with LIN28B to stabilize Wnt5a and boosts proliferation and migration of oxidized low densitylipoprotein-induced vascular smooth muscle cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2033401"}], "href": "https://doi.org/10.1080/21655979.2022.2033401"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35282771"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35282771"}]}]}]}