{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNA DPP10‑AS1 has emerged as a multifunctional regulator in both cancer and inflammatory disease contexts. In HER‑2–enriched breast cancer, it was identified as a core gene within coexpression networks, suggesting its involvement in tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In lung cancer, DPP10‑AS1 is significantly upregulated in tumor tissues where it epigenetically modulates the expression of its sense gene DPP10, thereby promoting malignant processes such as enhanced cell growth, invasion and resistance to apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, in colon cancer, functional studies implicate DPP10‑AS1 in the regulation of cancer stem cell properties through its interaction with miR‑127‑3p and ADCY1, which ultimately affects tumor growth dynamics."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, its dysregulated expression has been identified among key candidate biomarkers associated with immune cell infiltration in ulcerative colitis, indicating a potential role in modulating inflammatory responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Finally, in the setting of prostate cancer, increased expression of DPP10‑AS1 under treatment conditions contributes to chemoresistance by epigenetically enhancing FOXM1 expression, emphasizing its therapeutic as well as prognostic relevance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fan Yang, Shixu Lyu, Siyang Dong, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA DPP10-AS1 exerts anti-tumor effects on colon cancer "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "via"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " the upregulation of ADCY1 by regulating microRNA-127-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.202729"}], "href": "https://doi.org/10.18632/aging.202729"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33744851"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33744851"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Tianzhen He, Kai Wang, Peng Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrative computational approach identifies immune-relevant biomarkers in ulcerative colitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Open Bio (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/2211-5463.13357"}], "href": "https://doi.org/10.1002/2211-5463.13357"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34939750"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34939750"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yi Zhou, Zhien Zhou, Zhigang Ji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tetramethylpyrazine reduces prostate cancer malignancy through inactivation of the DPP10‑AS1/CBP/FOXM1 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2020.5036"}], "href": "https://doi.org/10.3892/ijo.2020.5036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32319592"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32319592"}]}]}]}