{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The available evidence from abstract"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "indicates that DPYD‐AS2, a non‐coding RNA located within the 1p21.3 genomic region, may play a regulatory role in neurodevelopment. In the context of the reported 3.56 Mb copy number gain that affected both coding and non‐coding genes, DPYD‐AS2 is suggested to contribute to the disturbance of cellular and intercellular homeostasis. This deregulation, when combined with altered gene dosage of key neurodevelopmental genes, is thought to underlie overlapping phenotypes observed in both 1p21.3 microdeletion and microduplication syndromes. Accordingly, the imbalance involving DPYD‐AS2 might affect the fine‐tuning of gene expression critical for cognitive and language development, thereby contributing to manifestations such as intellectual disability, severe speech deficits, and autistic spectrum behaviors.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lukrecija Brečević, Martina Rinčić, Željka Krsnik, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of new deletion/duplication region at chromosome 1p21 with intellectual disability, severe speech deficit and autism spectrum disorder-like behavior: an all-in approach to solving the "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "DPYD"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " enigma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Neurosci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1515/tnsci-2015-0007"}], "href": "https://doi.org/10.1515/tnsci-2015-0007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28123791"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28123791"}]}]}]}