DRG2 Gene

Name	developmentally regulated GTP binding protein 2
Description	This gene encodes a GTP-binding protein known to function in the regulation of cell growth and differentiation. Read-through transcripts containing this gene and a downstream gene have been identified, but they are not thought to encode a fusion protein. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jan 2012]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DRG2 is an evolutionarily conserved GTP‐binding protein that has emerged as a multifaceted regulator of cell physiology. Several studies indicate that DRG2 plays a critical role in controlling cell cycle progression at the G2/M transition by modulating the cyclin B1/Cdk1 complex; loss or overexpression of DRG2 leads to aberrant cell‐cycle arrest and altered sensitivity to mitotic inhibitors."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " In addition, DRG2 contributes to intracellular trafficking by facilitating Rab5 deactivation, thereby promoting transferrin recycling and the stability of endosomal membrane tubules through interactions that are dependent on Rac1 activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Its regulatory influence also extends to cytoskeletal dynamics; DRG2 helps modulate microtubule growth and spindle formation, factors critical for proper cell migration and Golgi organization, as further supported by live imaging studies of microtubule plus‐end dynamics."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Moreover, DRG2 maintains mitochondrial homeostasis by controlling the expression of the key fission factor Drp1, thereby influencing mitochondrial morphology, bioenergetics, and apoptotic sensitivity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond these roles in basic cellular function, DRG2 is increasingly implicated in tissue‐ and context-specific processes. In the central nervous system, for example, DRG2 is highly expressed in dopaminergic neurons and is essential for proper dopamine release, with knockout studies revealing motor deficits that are reversible with L‑DOPA supplementation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In cancer cells, altered DRG2 expression is linked to chemotherapeutic resistance and metastatic potential, as evidenced by its involvement in docetaxel‐induced cell cycle arrest in prostate cancer and its association with enhanced vascular endothelial growth factor expression and tumor metastasis in melanoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}, {"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " DRG2 also appears to influence differentiation processes in diverse cell types; for instance, its cooperation with peroxisome proliferator‑activated receptor‑γ (PPAR‑γ) promotes adipogenesis in models of obesity"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", while its effects on cytoskeletal reorganization underlie osteoclast fusion and activity that impact bone mass."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n At the level of gene regulation, DRG2 expression is modulated transcriptionally by factors such as Sp1 and is post‐translationally stabilized through specific binding to DFRP2, highlighting a tightly controlled regulatory network that ensures proper DRG2 function in both normal and pathological settings."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Furthermore, the high degree of sequence conservation observed across eukaryotes underscores its fundamental role in modulating cell growth, intracellular trafficking, and stress responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Soo Hwa Jang, Ah-Ram Kim, Neung-Hwa Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DRG2 Regulates G2/M Progression via the Cyclin B1-Cdk1 Complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cells (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14348/molcells.2016.0149"}], "href": "https://doi.org/10.14348/molcells.2016.0149"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27669826"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27669826"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hebok Song, Sin-Il Kim, Myoung Seok Ko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of DRG2 increases G2/M phase cells and decreases sensitivity to nocodazole-induced apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jb/mvh040"}], "href": "https://doi.org/10.1093/jb/mvh040"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15113831"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15113831"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Seong Cheol Kim, Won Hyeok Lee, Song Hee Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Developmentally regulated GTP-binding protein 2 levels in prostate cancer cell lines impact docetaxel-induced apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Investig Clin Urol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4111/icu.20200574"}], "href": "https://doi.org/10.4111/icu.20200574"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34190439"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34190439"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Muralidharan Mani, Unn Hwa Lee, Nal Ae Yoon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Developmentally regulated GTP-binding protein 2 coordinates Rab5 activity and transferrin recycling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E15-08-0558"}], "href": "https://doi.org/10.1091/mbc.E15-08-0558"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26582392"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26582392"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Muralidharan Mani, Dang Thi Thao, Beom Chang Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DRG2 knockdown induces Golgi fragmentation via GSK3β phosphorylation and microtubule stabilization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Mol Cell Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2019.06.003"}], "href": "https://doi.org/10.1016/j.bbamcr.2019.06.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31199931"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31199931"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Thao Dang, Soo Hwa Jang, Sung Hoon Back, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DRG2 Deficiency Causes Impaired Microtubule Dynamics in HeLa Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cells (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14348/molcells.2018.0129"}], "href": "https://doi.org/10.14348/molcells.2018.0129"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30453731"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30453731"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Mai-Tram Vo, Myoung Seok Ko, Unn Hwa Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Developmentally regulated GTP-binding protein 2 depletion leads to mitochondrial dysfunction through downregulation of dynamin-related protein 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2017.03.154"}], "href": "https://doi.org/10.1016/j.bbrc.2017.03.154"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28363867"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28363867"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hye Ryeong Lim, Mai-Tram Vo, Dong Jun Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DRG2 Deficient Mice Exhibit Impaired Motor Behaviors with Reduced Striatal Dopamine Release."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms21010060"}], "href": "https://doi.org/10.3390/ijms21010060"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31861806"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31861806"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jie Chen, Bai-Yong Shen, Xia-Xing Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SKP1-CULLIN1-F-box (SCF)-mediated DRG2 degradation facilitated chemotherapeutic drugs induced apoptosis in hepatocellular carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2012.03.058"}], "href": "https://doi.org/10.1016/j.bbrc.2012.03.058"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22450327"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22450327"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Byong Seo Park, Hye Li Im, Nal Ae Yoon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Developmentally regulated GTP-binding protein-2 regulates adipocyte differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2021.08.081"}], "href": "https://doi.org/10.1016/j.bbrc.2021.08.081"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34520979"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34520979"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Ke Ke, Ok-Joo Sul, Woon-Ki Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of developmentally regulated GTP-binding protein-2 increases bone loss."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Endocrinol Metab (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpendo.00517.2012"}], "href": "https://doi.org/10.1152/ajpendo.00517.2012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23360825"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23360825"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Hyo Jeong Kim, Myoung Seok Ko, Hong Kyung Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcription factor Sp1 regulates basal transcription of the human DRG2 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbagrm.2011.01.004"}], "href": "https://doi.org/10.1016/j.bbagrm.2011.01.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21296692"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21296692"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Kosuke Ishikawa, Sakura Azuma, Shuntaro Ikawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of DRG family regulatory proteins (DFRPs): specific regulation of DRG1 and DRG2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Cells (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2443.2005.00825.x"}], "href": "https://doi.org/10.1111/j.1365-2443.2005.00825.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15676025"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15676025"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "B Li, B Trueb "}, {"type": "b", "children": [{"type": "t", "text": "DRG represents a family of two closely related GTP-binding proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2000)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0167-4781(00)00025-7"}], "href": "https://doi.org/10.1016/s0167-4781(00"}, {"type": "t", "text": "00025-7) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "10760581"}], "href": "https://pubmed.ncbi.nlm.nih.gov/10760581"}]}]}]}
Proteins	DRG2_HUMAN
NCBI Gene ID	1819
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

DRG2 has 5,119 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 115 datasets.

Click the + buttons to view associations for DRG2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

DRG2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by DRG2 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DRG2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of DRG2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of DRG2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of DRG2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of DRG2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DRG2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of DRG2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DRG2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DRG2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of DRG2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of DRG2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with DRG2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with DRG2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DRG2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of DRG2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of DRG2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing DRG2 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of DRG2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing DRG2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing DRG2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing DRG2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with DRG2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with DRG2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of DRG2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with DRG2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with DRG2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by DRG2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with DRG2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with DRG2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with DRG2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with DRG2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with DRG2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at DRG2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DRG2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of DRG2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing DRG2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD High Level Gene-Disease Associations	diseases associated with DRG2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of DRG2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with DRG2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.