{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DSCAM‐AS1 is an oncogenic long noncoding RNA whose aberrant expression has been reported in multiple cancers, with its most extensive characterization in breast cancer. In estrogen receptor–positive breast tumors, DSCAM‐AS1 is directly regulated by ERα and contributes to tumor progression by promoting cell proliferation, migration, invasion, and tamoxifen resistance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": " Mechanistically, DSCAM‐AS1 functions as a competing endogenous RNA by sequestering tumor‐suppressor microRNAs—including miR‑204‑5p, miR‑137, miR‑101‑3p, among others—which results in the upregulation of key oncogenic effectors (such as RRM2, EPS8, ATXN7L3, and GPRC5A) that promote cell cycle progression and inhibit apoptosis. Similar ceRNA‐mediated mechanisms have been documented in cervical carcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "and"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", osteosarcoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "and"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ", non–small cell lung cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "and"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", colon cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ", and melanoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Overexpression of DSCAM‐AS1 is frequently correlated with aggressive clinical features, poor patient prognosis, and resistance to conventional therapies, highlighting its potential as both a diagnostic/prognostic biomarker and a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "15"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yashar S Niknafs, Sumin Han, Teng Ma, et al. 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