{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In cervical cancer, particularly in squamous cell carcinoma (SCC), distinct transcriptional networks contribute to the maintenance of the epithelial phenotype. One long non‐coding RNA that has emerged as part of this regulatory landscape is DSG1‐AS1. Although not explicitly detailed in the provided abstract, DSG1‐AS1 appears to function within a broader transcriptional regulatory program that is driven by key transcription factors associated with epithelial maintenance. In SCC, where pathways related to epithelial differentiation are preferentially active—as opposed to the MODY pathway noted in adenocarcinoma (ADC)—DSG1‐AS1 may participate in fine‐tuning gene expression linked to cell–cell adhesion and epithelial identity. This suggests that DSG1‐AS1 could play a contributory role in sustaining the epithelial characteristics that define SCC, potentially affecting tumor cell behavior through its regulation of nearby or functionally related desmoglein‐coding genes (such as DSG1)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Saloe Bispo, Ticiana D J Farias, Patricia Savio de Araujo-Souza, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dysregulation of Transcription Factor Networks Unveils Different Pathways in Human Papillomavirus 16-Positive Squamous Cell Carcinoma and Adenocarcinoma of the Uterine Cervix."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2021.626187"}], "href": "https://doi.org/10.3389/fonc.2021.626187"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34094909"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34094909"}]}]}]}