{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLncRNA DUBR has been identified as a tumor‐suppressive molecule in lung adenocarcinoma (LUAD). In LUAD, DUBR expression is significantly downregulated, and its lower levels are associated with a poorer prognosis. Mechanistically, c-Myc binds to the DUBR promoter and represses its transcription, leading to enhanced migration and invasion of LUAD cells. Conversely, overexpression of DUBR upregulates the downstream effector ZBTB11, which contributes to a reduction in oxidative phosphorylation and ultimately suppresses the invasive and migratory phenotypes of LUAD cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThese findings underscore the critical and context-specific roles of lncRNAs in cancer, highlighting how different lncRNA-mediated regulatory axes can impact tumor behavior. For example, while DUBR functions to inhibit malignancy in LUAD, other lncRNAs—such as Linc00883 in colorectal cancer—promote tumor progression through distinct pathways like the miR-577/FKBP14 axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wei Nie, Min-Juan Hu, Qin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DUBR suppresses migration and invasion of human lung adenocarcinoma cells via ZBTB11-mediated inhibition of oxidative phosphorylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Pharmacol Sin (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41401-021-00624-5"}], "href": "https://doi.org/10.1038/s41401-021-00624-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33758355"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33758355"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yang Bai, Ling Li, Zhiyong Zhang "}, {"type": "b", "children": [{"type": "t", "text": "Linc00883 affects colorectal cancer through miR-577/FKBP14 axis: a novel mechanism for regulating colorectal cancer cell proliferation, invasion, and migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2022.2097824"}], "href": "https://doi.org/10.1080/15384101.2022.2097824"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35833665"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35833665"}]}]}]}