DUSP10 Gene

HGNC Family	Phosphatases
Name	dual specificity phosphatase 10
Description	Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DUSP10, also known as MKP5, is a dual‐specificity protein phosphatase that serves as a critical negative regulator of mitogen‐activated protein kinase (MAPK) signaling. Studies using DUSP10 (MKP5)–deficient mouse cells have demonstrated that loss of this phosphatase leads to markedly enhanced activation of c‐Jun N‐terminal kinase (JNK) and a corresponding increase in proinflammatory cytokine production, indicating its essential role in tempering both innate and adaptive immune responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In redox‐regulated contexts, DUSP10 activity is safeguarded by interactions with proteins such as peroxiredoxin 1, which help preserve its function under oxidative stress and thereby maintain proper p38 MAPK signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In mesangial cells from diabetic models, reduced expression of DUSP10 contributes to unchecked JNK activation and a proinflammatory phenotype, whereas restoration of its expression mitigates these effects."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Moreover, rapid and transient induction of DUSP10 in response to oxidative stress has been shown to be key in fine‐tuning the magnitude of JNK activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Genetic studies have further implicated DUSP10 in human disease, with specific variants being associated with neurodegenerative disorders such as progressive supranuclear palsy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In immunoregulatory contexts, post‐transcriptional control by microRNAs—such as miR‑21, miR‑30b, and miR‑155 in CD8⁺ T suppressor cells—modulates DUSP10 expression and thereby influences T‐cell suppressive functions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Similarly, in pancreatic cancer cells, upregulation of miR‑92a targets and suppresses DUSP10 expression, resulting in enhanced JNK signaling and increased cell proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, DUSP10 expression is responsive to intracellular signaling cues that impact tissue homeostasis. For example, in colonic epithelium, activation of protein kinase G2 enhances DUSP10 levels to reduce JNK phosphorylation, thereby diminishing apoptosis and promoting differentiation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Conversely, in hepatocellular carcinoma, down‐regulation of DUSP10 has been linked to increased ERK pathway activation and metastatic progression, underscoring its context‐dependent tumor‐suppressive properties."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings establish DUSP10 as a pivotal modulator of MAPK signaling. By dephosphorylating and inactivating key MAPK components such as JNK (and, in certain contexts, p38), DUSP10 plays a central role in maintaining cellular homeostasis during inflammatory, oxidative, and oncogenic stress, making it a promising target for therapeutic intervention in a diverse array of disease settings.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yongliang Zhang, Joseph N Blattman, Norman J Kennedy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature02764"}], "href": "https://doi.org/10.1038/nature02764"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15306813"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15306813"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Debra J Taxman, Elizabeth A Holley-Guthrie, Max Tze-Han Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.221077"}], "href": "https://doi.org/10.1074/jbc.M111.221077"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21487011"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21487011"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "B Turner-Ivey, Y Manevich, J Schulte, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role for Prdx1 as a specific sensor in redox-regulated senescence in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2012.624"}], "href": "https://doi.org/10.1038/onc.2012.624"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23334324"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23334324"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jin Wu, Changlin Mei, Helen Vlassara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oxidative stress-induced JNK activation contributes to proinflammatory phenotype of aging diabetic mesangial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Renal Physiol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajprenal.00078.2009"}], "href": "https://doi.org/10.1152/ajprenal.00078.2009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19776174"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19776174"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Chun-Hung Teng, Wen-Nin Huang, Tzu-Ching Meng "}, {"type": "b", "children": [{"type": "t", "text": "Several dual specificity phosphatases coordinate to control the magnitude and duration of JNK activation in signaling response to oxidative stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M705142200"}], "href": "https://doi.org/10.1074/jbc.M705142200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17681939"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17681939"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Monica Y Sanchez-Contreras, Naomi Kouri, Casey N Cook, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Replication of progressive supranuclear palsy genome-wide association study identifies SLCO1A2 and DUSP10 as new susceptibility loci."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Neurodegener (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13024-018-0267-3"}], "href": "https://doi.org/10.1186/s13024-018-0267-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29986742"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29986742"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Chih-Chao Chang, Qing-Yin Zhang, Zhuoru Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of inflammatory microRNAs by Ig-like transcript 3 is essential for the differentiation of human CD8(+) T suppressor cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1102899"}], "href": "https://doi.org/10.4049/jimmunol.1102899"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22387553"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22387553"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Malin Östensson, Caroline Montén, Jonas Bacelis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0070174"}], "href": "https://doi.org/10.1371/journal.pone.0070174"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23936387"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23936387"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "R Wang, I-K Kwon, N Singh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Type 2 cGMP-dependent protein kinase regulates homeostasis by blocking c-Jun N-terminal kinase in the colon epithelium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cdd.2013.163"}], "href": "https://doi.org/10.1038/cdd.2013.163"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24270408"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24270408"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Kai-Yu Ng, Lok-Hei Chan, Stella Chai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TP53INP1 Downregulation Activates a p73-Dependent DUSP10/ERK Signaling Pathway to Promote Metastasis of Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-16-3456"}], "href": "https://doi.org/10.1158/0008-5472.CAN-16-3456"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28674078"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28674078"}]}]}]}
Synonyms	MKP-5, MKP5
Proteins	DUS10_HUMAN
NCBI Gene ID	11221
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

DUSP10 has 8,674 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 120 datasets.

Click the + buttons to view associations for DUSP10 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

DUSP10 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DUSP10 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of DUSP10 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of DUSP10 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of DUSP10 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of DUSP10 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DUSP10 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of DUSP10 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DUSP10 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DUSP10 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of DUSP10 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of DUSP10 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with DUSP10 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DUSP10 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of DUSP10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of DUSP10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of DUSP10 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing DUSP10 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing DUSP10 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing DUSP10 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with DUSP10 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with DUSP10 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of DUSP10 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with DUSP10 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with DUSP10 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with DUSP10 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by DUSP10 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with DUSP10 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with DUSP10 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with DUSP10 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with DUSP10 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with DUSP10 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at DUSP10 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DUSP10 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of DUSP10 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing DUSP10 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with DUSP10 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with DUSP10 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of DUSP10 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with DUSP10 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing DUSP10 from the GeneSigDB Published Gene Signatures dataset.