{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DUSP29 is a recently identified member of the dual‐specificity phosphatase family that appears to play a role in skeletal muscle homeostasis. In particular, there is emerging evidence that DUSP29 is involved in the regulation of muscle fiber structure and function, as its activity is linked with control over signaling pathways that govern myofiber maturation and maintenance. Although its precise substrates and molecular targets remain to be fully defined, dual‐specificity phosphatases typically dephosphorylate serine, threonine, and tyrosine residues and thereby modulate the activity of kinases implicated in muscle cell growth and differentiation. In the context of skeletal muscle atrophy—a process induced by denervation, immobilization, corticosteroid exposure, aging, and other stressors—aberrant regulation of phosphatases like DUSP29 may contribute to the disorganization of the contractile apparatus and decreased muscle strength. As such, DUSP29 is thought to be an important regulator of the signaling processes that maintain myofiber integrity, positioning it as a potential target for interventions designed to preserve muscle mass and function under atrophic conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lisa M Cooper, Rita C West, Caleb S Hayes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dual-specificity phosphatase 29 is induced during neurogenic skeletal muscle atrophy and attenuates glucocorticoid receptor activity in muscle cell culture."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Cell Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpcell.00200.2020"}], "href": "https://doi.org/10.1152/ajpcell.00200.2020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32639872"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32639872"}]}]}]}