|Name||double homeobox 4 like 1|
|Description||This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length and a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. There is no evidence for transcription of the gene at this locus though RT-PCR and in vitro expression experiments indicate that a telomeric paralog of this gene is transcribed in some haplotypes. Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). [provided by RefSeq, Jun 2014]|
|NCBI Gene ID||22947|
|Expression in Tissues and Cell Lines||
DUX4L1 has 380 functional associations with biological entities spanning 2 categories (functional term, phrase or reference, cell line, cell type or tissue) extracted from 4 datasets.
Click the + buttons to view associations for DUX4L1 from the datasets below.
If available, associations are ranked by standardized value
|GeneRIF Biological Term Annotations||biological terms co-occuring with DUX4L1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.|
|Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles||cell lines with high or low copy number of DUX4L1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.|
|LOCATE Curated Protein Localization Annotations||cellular components containing DUX4L1 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset.|
|LOCATE Predicted Protein Localization Annotations||cellular components predicted to contain DUX4L1 protein from the LOCATE Predicted Protein Localization Annotations dataset.|