{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DYNLT5 is a member of the dynein light chain family that contributes to the proper function of the cytoplasmic dynein motor complex, a key player in microtubule‐mediated intracellular transport. Experimental evidence indicates that DYNLT5 is involved in ciliary assembly and function by mediating the trafficking of proteins required for retrograde intraflagellar transport and basal body homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, DYNLT5 interacts with regulatory molecules such as protein phosphatase PPP1 to influence microtubule dynamics, which is critical for processes including sperm flagellar motility, acrosome formation, and the regulation of the blood–testis barrier."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Beyond its cell biological roles, genetic studies have linked alterations in DYNLT5 isoforms (e.g., TCTEX1D1) to human disease phenotypes; variants in this gene are associated with an accelerated loss of ambulation in Duchenne muscular dystrophy"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", its differential expression serves as a prognostic biomarker in clear cell renal cell carcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", and it has been identified in transcriptome‐wide analyses as a risk gene for depression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Collectively, these findings support the view that DYNLT5 is integral not only to fundamental intracellular and organellar transport processes but also to the modulation of complex disease phenotypes, thereby positioning it as a potentially important therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ankur A Gholkar, Silvia Senese, Yu-Chen Lo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tctex1d2 associates with short-rib polydactyly syndrome proteins and is required for ciliogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/15384101.2014.985066"}], "href": "https://doi.org/10.4161/15384101.2014.985066"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25830415"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25830415"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Luís Korrodi-Gregório, Sandra I Vieira, Sara L C Esteves, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TCTEX1D4, a novel protein phosphatase 1 interactor: connecting the phosphatase to the microtubule network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Open (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/bio.20131065"}], "href": "https://doi.org/10.1242/bio.20131065"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23789093"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23789093"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Pietro Spitali, Irina Zaharieva, Stefan Bohringer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TCTEX1D1 is a genetic modifier of disease progression in Duchenne muscular dystrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41431-019-0563-6"}], "href": "https://doi.org/10.1038/s41431-019-0563-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31896777"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31896777"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jingmin Zhou, Guanghua Liu, Xingcheng Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Risk Score Model Based on Nine Differentially Methylated mRNAs for Predicting Prognosis of Patients with Clear Cell Renal Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dis Markers (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/8863799"}], "href": "https://doi.org/10.1155/2021/8863799"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33510822"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33510822"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xiaoyan Li, Xi Su, Jiewei Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptome-wide association study identifies new susceptibility genes and pathways for depression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Psychiatry (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41398-021-01411-w"}], "href": "https://doi.org/10.1038/s41398-021-01411-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34021117"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34021117"}]}]}]}