DYRK1B Gene

Name	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
Description	This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DYRK1B (also known as Mirk) is a multifunctional dual‐specificity kinase that plays context‐dependent roles in regulating cell motility, cell cycle progression, differentiation, metabolism, and survival. In cancer cells, for example, RNA interference of DYRK1B reduced cell migration in ovarian carcinoma models"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "and impaired clonogenic growth and stress resistance in pancreatic and osteosarcoma models"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", highlighting its critical role in supporting tumor cell survival. At the molecular level, DYRK1B phosphorylates key cell cycle regulators: it mediates phosphorylation of the cyclin‐dependent kinase inhibitor p27 at serine 10, thereby stabilizing p27 and reinforcing G0/G1 arrest"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", while phosphorylation of cyclin D1 on threonine residues (notably Thr286) marks it for proteasomal degradation to further impede cell cycle progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": " Such regulation is evident in quiescent tumor cells where DYRK1B activity modulates cyclin D turnover and cooperates with p27 to control cell cycle exit."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to cell cycle control, DYRK1B contributes to differentiation and metabolic signaling. During myogenesis, DYRK1B phosphorylates class II histone deacetylases to relieve MEF2 inhibition and promote expression of myogenic genes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " In the context of metabolic regulation, gain‐of‐function mutations in DYRK1B enhance adipogenesis and gluconeogenesis—by potentiating the inhibition of the Sonic Hedgehog and Wnt pathways as well as up‐regulating glucose‐6‐phosphatase expression—thereby linking DYRK1B to an inherited form of metabolic syndrome."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Moreover, DYRK1B can act as a positive regulator of Hedgehog/GLI signaling downstream of Smoothened, supporting GLI1 expression in both SMO‐sensitive and –resistant settings."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n DYRK1B also integrates signals from diverse pathways. In cardiac tissue, its overexpression is associated with impaired mitochondrial bioenergetics via enhanced STAT3 phosphorylation and subsequent down‐regulation of PGC‐1α, contributing to cardiac hypertrophy and failure; conversely, loss of DYRK1B ameliorates these defects."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " In reproductive biology, DYRK1B interacts with the cold‐inducible RNA‐binding protein Cirp in spermatogonia, modulating the phosphorylation status and stability of p27 and cyclin D1 to finely tune the proliferation of undifferentiated germ cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " Furthermore, in ovarian cancer cells, DYRK1B supports cell survival by controlling the subcellular localization of FoxO transcription factors, thereby modulating chemosensitivity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " Finally, in pancreatic β‐cells, dual inhibition of DYRK1B alongside DYRK1A is required to achieve maximal proliferation, suggesting that DYRK1B can serve as a brake on cell regeneration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies underscore the diverse and critical functions of DYRK1B as a regulator of proliferation, differentiation, metabolic homeostasis, and survival, making it a promising target for therapeutic intervention in cancer, metabolic disorders, and cardiovascular diseases.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Cynthia S Collins, Jiyong Hong, Lisa Sapinoso, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0600040103"}], "href": "https://doi.org/10.1073/pnas.0600040103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16537454"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16537454"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaobing Deng, Daina Z Ewton, Sheena Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The kinase Mirk/Dyrk1B mediates cell survival in pancreatic ductal adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-05-3089"}], "href": "https://doi.org/10.1158/0008-5472.CAN-05-3089"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16618736"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16618736"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiaobing Deng, Stephen E Mercer, Sejal Shah, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The cyclin-dependent kinase inhibitor p27Kip1 is stabilized in G(0) by Mirk/dyrk1B kinase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M400479200"}], "href": "https://doi.org/10.1074/jbc.M400479200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15010468"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15010468"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yelena Janumyan, Qinghua Cui, Ling Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "G0 function of BCL2 and BCL-xL requires BAX, BAK, and p27 phosphorylation by Mirk, revealing a novel role of BAX and BAK in quiescence regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M806294200"}], "href": "https://doi.org/10.1074/jbc.M806294200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18818203"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18818203"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yonglong Zou, Daina Z Ewton, Xiaobing Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mirk/dyrk1B kinase destabilizes cyclin D1 by phosphorylation at threonine 288."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M403042200"}], "href": "https://doi.org/10.1074/jbc.M403042200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15075324"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15075324"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Anne L Ashford, David Oxley, Jason Kettle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr(286), not Thr(288)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20130461"}], "href": "https://doi.org/10.1042/BJ20130461"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24134204"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24134204"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Fumi Takahashi-Yanaga, Jun Mori, Etsuko Matsuzaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of GSK-3beta and DYRK1B in differentiation-inducing factor-3-induced phosphorylation of cyclin D1 in HeLa cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M605205200"}], "href": "https://doi.org/10.1074/jbc.M605205200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17046823"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17046823"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "PMID:19542203"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Xiaobing Deng, Daina Z Ewton, Stephen E Mercer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mirk/dyrk1B decreases the nuclear accumulation of class II histone deacetylases during skeletal muscle differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M411894200"}], "href": "https://doi.org/10.1074/jbc.M411894200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15546868"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15546868"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Ali R Keramati, Mohsen Fathzadeh, Gwang-Woong Go, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A form of the metabolic syndrome associated with mutations in DYRK1B."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "N Engl J Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1056/NEJMoa1301824"}], "href": "https://doi.org/10.1056/NEJMoa1301824"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24827035"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24827035"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Wolfgang Gruber, Martin Hutzinger, Dominik Patrick Elmer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.6910"}], "href": "https://doi.org/10.18632/oncotarget.6910"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26784250"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26784250"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Matthias Lauth, Asa Bergström, Takashi Shimokawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb.1833"}], "href": "https://doi.org/10.1038/nsmb.1833"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20512148"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20512148"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Lingfang Zhuang, Kangni Jia, Chen Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCULATIONAHA.121.055727"}], "href": "https://doi.org/10.1161/CIRCULATIONAHA.121.055727"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35235343"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35235343"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Tomoko Masuda, Katsuhiko Itoh, Hiroaki Higashitsuji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cold-inducible RNA-binding protein (Cirp) interacts with Dyrk1b/Mirk and promotes proliferation of immature male germ cells in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1121524109"}], "href": "https://doi.org/10.1073/pnas.1121524109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22711815"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22711815"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jingchun Gao, Xiangjun Yang, Ping Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The involvement of FoxO in cell survival and chemosensitivity mediated by Mirk/Dyrk1B in ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2011.1293"}], "href": "https://doi.org/10.3892/ijo.2011.1293"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22159921"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22159921"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Courtney Ackeifi, Ethan Swartz, Kunal Kumar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pharmacologic and genetic approaches define human pancreatic β cell mitogenic targets of DYRK1A inhibitors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JCI Insight (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/jci.insight.132594"}], "href": "https://doi.org/10.1172/jci.insight.132594"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31821176"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31821176"}]}]}]}
Synonyms	MIRK, AOMS3
Proteins	DYR1B_HUMAN
NCBI Gene ID	9149
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

DYRK1B has 5,830 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 120 datasets.

Click the + buttons to view associations for DYRK1B from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

DYRK1B Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by DYRK1B gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DYRK1B gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of DYRK1B gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of DYRK1B gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of DYRK1B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of DYRK1B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DYRK1B gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of DYRK1B gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DYRK1B gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DYRK1B gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of DYRK1B gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of DYRK1B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of DYRK1B gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with DYRK1B gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DYRK1B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of DYRK1B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of DYRK1B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with DYRK1B gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of DYRK1B gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing DYRK1B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing DYRK1B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with DYRK1B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with DYRK1B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of DYRK1B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with DYRK1B gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with DYRK1B gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with DYRK1B gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by DYRK1B gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving DYRK1B gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving DYRK1B gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with DYRK1B gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with DYRK1B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with DYRK1B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with DYRK1B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with DYRK1B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at DYRK1B gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DYRK1B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of DYRK1B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing DYRK1B from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of DYRK1B gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.