{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have increasingly implicated the long non‐coding RNA EBLN3P—a member of the endogenous bornavirus‐like nucleoprotein family—in the regulation of diverse pathological processes. In osteosarcoma, EBLN3P functions as a competing endogenous RNA by sponging miR‑224‑5p, thereby relieving its suppression of Rab10 and promoting tumor cell proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the context of sensorineural hearing loss, high expression of EBLN3P in normal spiral ganglion neurons supports cell viability and inhibits apoptosis by competitively binding miR‑204‑5p, which in turn regulates TMPRSS3 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n EBLN3P has also been shown to contribute to hematologic and solid tumor progression. In T‑cell acute lymphoblastic leukemia, upregulation of EBLN3P promotes malignant behaviors by sequestering miR‑655‑3p"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", while in lung adenocarcinoma silencing EBLN3P leads to increased miR‑655‑3p levels, reduced Bcl‑2 expression, inhibition of cell viability, and enhanced apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In breast cancer, particularly in the luminal B subtype, elevated EBLN3P expression is associated with suppression of immune responses and disease progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Network analyses in additional pathologic contexts further underscore the regulatory potential of this lncRNA. In hypertrophic scar formation, EBLN3P is part of a ceRNA network and is upregulated in correlation with ubiquitination‐related genes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Moreover, in acute myocardial infarction, systems biology approaches have identified EBLN3 among a panel of key lncRNAs associated with transcriptional regulation, protein phosphorylation, and signal transduction pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, the original discovery of endogenous bornavirus‐like nucleoprotein (EBLN) elements in the genomes of mammals highlights their evolutionary integration and raises the possibility that these viral‐derived sequences may confer novel regulatory functions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Collectively, these findings indicate that EBLN3P primarily acts as a molecular “sponge” for specific microRNAs to modulate gene expression, thereby influencing cell proliferation, apoptosis, migration, and immune response across a range of diseases.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shuhong Dai, Ning Li, Ming Zhou, et al. 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