{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have shown that lncRNA EBLN3P plays an oncogenic role in osteosarcoma. In osteosarcoma tissues and cell lines, EBLN3P is upregulated and acts as a competitive endogenous RNA (ceRNA) by sponging miR-224-5p, thereby relieving miR-224-5p–mediated inhibition of Rab10. This regulation leads to enhanced Rab10 expression, which in turn promotes cell proliferation, migration, and invasion, contributing to osteosarcoma progression and potentially affecting therapeutic responsiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in osteosarcoma, lncRNA EBLN3P is also implicated in T-cell acute lymphoblastic leukemia (T-ALL). In T-ALL cell lines, elevated levels of EBLN3P were found to suppress miR-655-3p expression. This suppression alleviates miR-655-3p–mediated inhibition of targets such as matrix metalloproteinase-9 (MMP-9), resulting in increased cell proliferation, invasion, and migration while reducing apoptotic events. The mechanistic insight into the EBLN3P/miR-655-3p axis further highlights its potential as a therapeutic target in T-ALL."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shuhong Dai, Ning Li, Ming Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA EBLN3P promotes the progression of osteosarcoma through modifying the miR-224-5p/Rab10 signaling axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-021-81641-6"}], "href": "https://doi.org/10.1038/s41598-021-81641-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33479458"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33479458"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ming-Xia Sun, Hai-Yan An, Yan-Bin Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA EBLN3P attributes methotrexate resistance in osteosarcoma cells through miR-200a-3p/O-GlcNAc transferase pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Orthop Surg Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13018-022-03449-y"}], "href": "https://doi.org/10.1186/s13018-022-03449-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36544170"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36544170"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jinhua Yang, Yingying Yang "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA endogenous bornavirus-like nucleoprotein acts as an oncogene by regulating microRNA-655-3p expression in T-cell acute lymphoblastic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2044249"}], "href": "https://doi.org/10.1080/21655979.2022.2044249"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35220878"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35220878"}]}]}]}