| Name | Ecm29 proteasome adaptor and scaffold |
| Description | Enables proteasome binding activity. Involved in ERAD pathway. Located in several cellular components, including centrosome; cytoplasmic vesicle; and nucleoplasm. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ECPAS, the proteasome‐associated protein also known as Ecm29, is a large (approximately 200‐kDa), HEAT repeat–containing adaptor that selectively binds to fully assembled 26S proteasomes. It functions to tether the core particle to its regulatory particles, thereby stabilizing the proteasome complex and modulating its assembly and integrity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In doing so, ECPAS not only influences the activation of associated deubiquitinating enzymes and the overall rate of ubiquitin‐dependent proteolysis but also appears to play a role in remodeling proteasome complexes under conditions of cellular stress."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": " Furthermore, by functioning as a molecular scaffold, ECPAS facilitates the targeted localization and redistribution of proteasomes to distinct cellular compartments – for example, coupling proteasomes to elements of the cytoskeleton and molecular motors to ensure proper positioning within secretory organelles, endosomes, and neuronal regions such as the axon initial segment, where it modulates the local abundance of proteins critical for processes like the GABAergic response switch."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Alterations in ECPAS levels or interactions, as observed under conditions of oxidative or proteotoxic stress – including during ethanol metabolism – correlate with impaired proteasome regulation and diminished clearance of damaged proteins."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Collectively, these findings underscore the multifaceted role of ECPAS as an essential adaptor protein that couples proteasome functionality to diverse cellular processes and stress responses.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Carlos Gorbea, Geoffrey M Goellner, Ken Teter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of mammalian Ecm29, a 26 S proteasome-associated protein that localizes to the nucleus and membrane vesicles."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M410444200"}], "href": "https://doi.org/10.1074/jbc.M410444200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15496406"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15496406"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Carlos Gorbea, Gregory Pratt, Vicença Ustrell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.154120"}], "href": "https://doi.org/10.1074/jbc.M110.154120"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20682791"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20682791"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "David S Leggett, John Hanna, Anna Borodovsky, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multiple associated proteins regulate proteasome structure and function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1097-2765(02)00638-x"}], "href": "https://doi.org/10.1016/s1097-2765(02"}, {"type": "t", "text": "00638-x) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12408819"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12408819"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Andrea Lehmann, Agathe Niewienda, Katharina Jechow, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ecm29 fulfils quality control functions in proteasome assembly."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2010.06.016"}], "href": "https://doi.org/10.1016/j.molcel.2010.06.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20620957"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20620957"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Olesya O Panasenko, Martine A Collart "}, {"type": "b", "children": [{"type": "t", "text": "Not4 E3 ligase contributes to proteasome assembly and functional integrity in part through Ecm29."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01210-10"}], "href": "https://doi.org/10.1128/MCB.01210-10"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21321079"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21321079"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Min Lee, Yen-Chen Liu, Chen Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201903033"}], "href": "https://doi.org/10.1083/jcb.201903033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31910261"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31910261"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Marie-Pierre Bousquet-Dubouch, Sheila Nguen, David Bouyssié, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chronic ethanol feeding affects proteasome-interacting proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proteomics (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pmic.200800959"}], "href": "https://doi.org/10.1002/pmic.200800959"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19609968"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19609968"}]}]}]}
|
| NCBI Gene ID | 23392 |
| API | |
| Download Associations | |
| Predicted Functions |
 |
| Co-expressed Genes |
|
| Expression in Tissues and Cell Lines |
|
ECPAS has 3,811 functional associations with biological entities spanning 5 categories (chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 38 datasets.
Click the + buttons to view associations for ECPAS from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of ECPAS gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Carcinogenome Chemical Perturbation Carcinogenicity Signatures | small molecule perturbations changing expression of ECPAS gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset. | |
| CCLE Cell Line Proteomics | Cell lines associated with ECPAS protein from the CCLE Cell Line Proteomics dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with ECPAS gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of ECPAS gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of ECPAS gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing ECPAS protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with ECPAS protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by ECPAS gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with ECPAS gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with ECPAS gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with ECPAS gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving ECPAS gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving ECPAS gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing ECPAS protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing ECPAS protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of ECPAS gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of ECPAS gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with ECPAS gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| IMPC Knockout Mouse Phenotypes | phenotypes of mice caused by ECPAS gene knockout from the IMPC Knockout Mouse Phenotypes dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of ECPAS gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of ECPAS gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of ECPAS gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of ECPAS gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by ECPAS gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of ECPAS gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of ECPAS gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of ECPAS gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of ECPAS gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of ECPAS gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of ECPAS gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of ECPAS gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of ECPAS gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Sci-Plex Drug Perturbation Signatures | drug perturbations changing expression of ECPAS gene from the Sci-Plex Drug Perturbation Signatures dataset. | |
| Tahoe Therapeutics Tahoe 100M Perturbation Atlas | drug perturbations changing expression of ECPAS gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of ECPAS protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of ECPAS protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with ECPAS protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
