{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Although the study (1) focused on polymorphisms within the EDNRB gene rather than directly addressing EDNRB‐AS1, the findings provide insight into a regulatory region that may include antisense elements such as EDNRB‐AS1. In this work, genetic variants in the EDNRB locus were found to be significantly associated with obesity risk, with certain alleles showing a protective effect against obesity and an interaction with elevated plasma arsenic levels. Given that EDNRB‐AS1 is an antisense RNA transcript to the EDNRB gene, it is plausible that this long noncoding RNA plays a role in modulating EDNRB expression. Such modulation could influence endothelin signaling pathways that are involved in lipolysis, adipocyte function, and ultimately lipid metabolism. This regulatory role might help explain how alterations in the expression or function of the EDNRB locus—including contributions from regulatory transcripts like EDNRB‐AS1—could impact susceptibility to obesity. \n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n (1)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Vanesa Martínez-Barquero, Griselda de Marco, Sergio Martínez-Hervas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphisms in endothelin system genes, arsenic levels and obesity risk."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0118471"}], "href": "https://doi.org/10.1371/journal.pone.0118471"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25799405"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25799405"}]}]}]}