{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n EEF1AKMT3 is emerging as a novel lysine‐specific methyltransferase that appears to target the eukaryotic translation elongation factor 1A (eEF1A), a key regulator of protein synthesis and cytoskeletal organization. Although its characterization is less advanced compared with that of related enzymes—such as METTL21B, which methylates eEF1A at Lys‐165 to modulate translation and chaperone functions"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", and EEF1AKMT4, which catalyzes methylation at Lys‐36 and alters translation dynamics"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "—recent transcriptomic analyses have identified changes in eef1akmt3 expression under acute environmental stress. In studies examining gonadal responses to high temperature, for example, eef1akmt3 was found among a set of genes (together with other methyltransferases and heat shock proteins) that are responsive to thermal stress, suggesting a role in adapting the translational machinery to environmental cues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, given that alterations in the genomic regulation and expression of eEF1A‐targeting methyltransferases have been associated with malignant transformation and immune modulation, EEF1AKMT3 may also partake in the molecular processes that underlie tumor progression and disease pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Overall, by catalyzing lysine methylation on eEF1A, EEF1AKMT3 is posited to fine‐tune translation and cellular homeostasis, thereby contributing to both stress adaptation and disease‐related cellular reprogramming.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jedrzej Malecki, Vinay Kumar Aileni, Angela Y Y Ho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The novel lysine specific methyltransferase METTL21B affects mRNA translation through inducible and dynamic methylation of Lys-165 in human eukaryotic elongation factor 1 alpha (eEF1A)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkx002"}], "href": "https://doi.org/10.1093/nar/gkx002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28108655"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28108655"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Magnus E Jakobsson, Jedrzej Malecki, Benedikt S Nilges, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methylation of human eukaryotic elongation factor alpha (eEF1A) by a member of a novel protein lysine methyltransferase family modulates mRNA translation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkx432"}], "href": "https://doi.org/10.1093/nar/gkx432"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28520920"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28520920"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Qian Wang, Xiancai Hao, Kaiqiang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Early response to heat stress in Chinese tongue sole (Cynoglossus semilaevis): performance of different sexes, candidate genes and networks."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Genomics (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12864-020-07157-x"}], "href": "https://doi.org/10.1186/s12864-020-07157-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33109079"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33109079"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xin Shu, Xinquan Li, Xiaochen Xiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "METTL21B is a prognostic biomarker and potential therapeutic target in low-grade gliomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.203454"}], "href": "https://doi.org/10.18632/aging.203454"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34446611"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34446611"}]}]}]}