EFNB3 Gene

HGNC Family	Ephrins (EFN)
Name	ephrin-B3
Description	EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. Moreover, since levels of EFNB3 expression were particularly high in several forebrain subregions compared to other brain subregions, it may play a pivotal role in forebrain function. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH Receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Ephrin‐B3 (EFNB3) is a multifunctional transmembrane protein that plays diverse roles in the nervous and immune systems by functioning both as a ligand and, via reverse signaling, as a receptor. In neural circuit formation, EFNB3 interacts with Eph receptors (e.g., EphA4) to provide repulsive cues that regulate growth cone extension, axon pruning, and proper motor circuit wiring required for coordinated left–right alternation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " In the adult central nervous system, EFNB3 is expressed in myelinating oligodendrocytes where it contributes to myelin‐derived inhibitory activity on axon regeneration; indeed, deletion of EFNB3 leads to enhanced regrowth of injured axons and improved locomotor recovery."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Moreover, EFNB3 serves as a high‐affinity receptor for emerging paramyxoviruses such as Nipah virus, enabling viral entry through specific interactions with the viral attachment protein."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n At the synaptic level, EFNB3 reverse signaling modulates dendritic architecture and glutamatergic connectivity by controlling the formation of shaft synapses and regulating postsynaptic scaffold stability via interactions with PDZ‐domain proteins (e.g., GRIP1, PICK1, and syntenin) and key signaling mediators; consequently, EFNB3 helps fine‐tune synapse density and plasticity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "9"}]}, {"type": "t", "text": " EFNB3 levels at the cell surface are further regulated by proteolytic cleavage through the activity of the rhomboid protease RHBDL2, which may control the extent of its signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In pathological contexts, increased EFNB3 expression has been implicated in promoting glioma cell migration and invasion through Rac1‐dependent pathways, suggesting an important role in tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Beyond the nervous system, EFNB3 expressed on peripheral T cells enhances activation, as evidenced by augmented proliferation, interferon‐γ production, and cytotoxic activity following EFNB3 costimulation that involves MAP kinase signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Furthermore, in neural stem cell niches such as the subventricular zone and the hippocampus, EFNB3 plays a regulatory role in controlling progenitor cell proliferation and survival, thereby helping to maintain balanced neurogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " In addition, EFNB3 signaling influences astrocyte function by modulating d-serine synthesis and release, further contributing to synaptic plasticity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies illustrate that EFNB3 is a critical regulator of axon guidance, synapse formation, and neural regeneration, while also modulating immune cell activation and contributing to oncogenic invasion. The diverse roles of EFNB3 underscore its therapeutic potential in regenerative medicine, neuroprotection, viral infection, and cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Klas Kullander, Simon J B Butt, James M Lebret, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of EphA4 and EphrinB3 in local neuronal circuits that control walking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1079641"}], "href": "https://doi.org/10.1126/science.1079641"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12649481"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12649481"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Takuji Iwasato, Hironori Katoh, Hiroshi Nishimaru, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2007.07.022"}], "href": "https://doi.org/10.1016/j.cell.2007.07.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17719550"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17719550"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Nan-Jie Xu, Mark Henkemeyer "}, {"type": "b", "children": [{"type": "t", "text": "Ephrin-B3 reverse signaling through Grb4 and cytoskeletal regulators mediates axon pruning."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Neurosci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nn.2254"}], "href": "https://doi.org/10.1038/nn.2254"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19182796"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19182796"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "M Douglas Benson, Mario I Romero, Mark E Lush, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ephrin-B3 is a myelin-based inhibitor of neurite outgrowth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0504021102"}], "href": "https://doi.org/10.1073/pnas.0504021102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16020529"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16020529"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Philip Duffy, Xingxing Wang, Chad S Siegel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myelin-derived ephrinB3 restricts axonal regeneration and recovery after adult CNS injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1113953109"}], "href": "https://doi.org/10.1073/pnas.1113953109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22411787"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22411787"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Oscar A Negrete, Mike C Wolf, Hector C Aguilar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Two key residues in ephrinB3 are critical for its use as an alternative receptor for Nipah virus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Pathog (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.ppat.0020007"}], "href": "https://doi.org/10.1371/journal.ppat.0020007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16477309"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16477309"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jason Aoto, Pamela Ting, Bita Maghsoodi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Postsynaptic ephrinB3 promotes shaft glutamatergic synapse formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.0705-07.2007"}], "href": "https://doi.org/10.1523/JNEUROSCI.0705-07.2007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17626212"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17626212"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Nan-Jie Xu, Suya Sun, Jay R Gibson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A dual shaping mechanism for postsynaptic ephrin-B3 as a receptor that sculpts dendrites and synapses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Neurosci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nn.2931"}], "href": "https://doi.org/10.1038/nn.2931"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21964490"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21964490"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Alma Rodenas-Ruano, Miguel A Perez-Pinzon, Edward J Green, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct roles for ephrinB3 in the formation and function of hippocampal synapses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2006.01.004"}], "href": "https://doi.org/10.1016/j.ydbio.2006.01.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16466709"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16466709"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "John C Pascall, Kenneth D Brown "}, {"type": "b", "children": [{"type": "t", "text": "Intramembrane cleavage of ephrinB3 by the human rhomboid family protease, RHBDL2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2004.03.039"}], "href": "https://doi.org/10.1016/j.bbrc.2004.03.039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15047175"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15047175"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Mitsutoshi Nakada, Kelsey L Drake, Satoko Nakada, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ephrin-B3 ligand promotes glioma invasion through activation of Rac1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-05-4211"}], "href": "https://doi.org/10.1158/0008-5472.CAN-05-4211"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16951161"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16951161"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Guang Yu, Hongyu Luo, Yulian Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mouse ephrinB3 augments T-cell signaling and responses to T-cell receptor ligation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M306659200"}], "href": "https://doi.org/10.1074/jbc.M306659200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "13679370"}], "href": "https://pubmed.ncbi.nlm.nih.gov/13679370"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Michelle H Theus, Jerome Ricard, John R Bethea, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EphB3 limits the expansion of neural progenitor cells in the subventricular zone by regulating p53 during homeostasis and following traumatic brain injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/stem.449"}], "href": "https://doi.org/10.1002/stem.449"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20496368"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20496368"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Michael J Chumley, Timothy Catchpole, Robert E Silvany, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EphB receptors regulate stem/progenitor cell proliferation, migration, and polarity during hippocampal neurogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.4158-07.2007"}], "href": "https://doi.org/10.1523/JNEUROSCI.4158-07.2007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18057206"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18057206"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Zhiye Zhuang, Bing Yang, Michelle H Theus, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EphrinBs regulate D-serine synthesis and release in astrocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.0481-10.2010"}], "href": "https://doi.org/10.1523/JNEUROSCI.0481-10.2010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21106840"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21106840"}]}]}]}
Synonyms	EFL6, EPLG8, LERK8
Proteins	EFNB3_HUMAN
NCBI Gene ID	1949
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

EFNB3 has 6,131 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 110 datasets.

Click the + buttons to view associations for EFNB3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

EFNB3 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of EFNB3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of EFNB3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of EFNB3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of EFNB3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of EFNB3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of EFNB3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of EFNB3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of EFNB3 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of EFNB3 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of EFNB3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of EFNB3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with EFNB3 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of EFNB3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of EFNB3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of EFNB3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of EFNB3 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing EFNB3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing EFNB3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with EFNB3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with EFNB3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of EFNB3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with EFNB3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with EFNB3 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with EFNB3 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by EFNB3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with EFNB3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with EFNB3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with EFNB3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with EFNB3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with EFNB3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at EFNB3 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of EFNB3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of EFNB3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing EFNB3 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with EFNB3 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with EFNB3 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of EFNB3 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with EFNB3 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing EFNB3 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of EFNB3 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.