{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n This overview integrates insights from two studies examining noncoding RNAs in distinct biological processes. While one study broadly reviews the profile and potential roles of extracellular RNAs—including long noncoding RNAs—in aging and disease (see"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", the other specifically characterizes liver cancer–associated ceRNA networks in HBV-related hepatocarcinogenesis. Within the latter investigation, the long noncoding RNA EHHADH-AS1 is identified as a key component of a ceRNA network involving hsa‐miR‐4459 and ENTPD5. In this context, EHHADH-AS1 appears to modulate molecular interactions that may contribute to liver cancer development. Notably, treatment with compound K—an intestinal bacterial metabolite of ginseng—was found to counteract the down‐regulation of EHHADH-AS1 in several hepatocellular carcinoma cell lines, suggesting that modulation of EHHADH-AS1 expression could influence tumor cell survival and apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Douglas F Dluzen, Nicole Noren Hooten, Michele K Evans "}, {"type": "b", "children": [{"type": "t", "text": "Extracellular RNA in aging."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Wiley Interdiscip Rev RNA (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/wrna.1385"}], "href": "https://doi.org/10.1002/wrna.1385"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27531497"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27531497"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Quan Wen, Dong Wang, Yao Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Competing endogenous RNA screening based on long noncoding RNA-messenger RNA co-expression profile in Hepatitis B virus-associated hepatocarcinogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Tradit Chin Med (2017)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32188210"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32188210"}]}]}]}