{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have revealed that the long noncoding RNA EIF3J‐AS1 plays a multifaceted oncogenic role in various malignancies and may also serve as a prognostic biomarker. In hepatocellular carcinoma, EIF3J‐AS1 is markedly upregulated in tumor tissues and cell lines, where its increased expression correlates with poor prognosis. Functional assays have demonstrated that EIF3J‐AS1 promotes cell proliferation, migration, and invasion, in part by acting as a competing endogenous RNA (ceRNA) that sequesters miR‐122-5p to derepress CTNND2 expression; moreover, hypoxic conditions can induce its expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In colorectal cancer, elevated levels of EIF3J‐AS1—upregulated through H3K27 acetylation at its promoter—enhance tumor cell proliferation and inhibit apoptosis via the ceRNA mechanism involving miR‐3163 and YAP1, underscoring its association with poor patient outcome."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, in esophageal cancer, EIF3J‐AS1 promotes disease progression by sponging miR‐373-3p, thus elevating AKT1 mRNA levels and correlating with advanced tumor stage and reduced survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In glioma, functional studies reveal that EIF3J‐AS1 facilitates malignant behaviors via the miR‐1343-3p/ANXA11 axis, while in prostate cancer it appears to contribute to tumor progression by positively regulating MAFG expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Beyond cancer, EIF3J‐AS1 has been identified among key hub lncRNAs associated with dilated cardiomyopathy, where it is predicted to function through ceRNA crosstalk."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Additionally, its inclusion in a six‐lncRNA signature for predicting hepatocellular carcinoma recurrence further highlights its potential clinical utility as a prognostic marker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xue Yang, Bowen Yao, Yongshen Niu, et al. 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