{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that lncRNAs transcribed from the EIF3J locus play critical roles in modulating cancer cell survival and drug responsiveness. For instance, lncRNA EIF3J-DT is highly expressed in drug‐resistant gastric cancer cells, where it activates autophagy and promotes chemoresistance by upregulating ATG14. It achieves this by directly binding to and stabilizing ATG14 mRNA, as well as by competing with miR-188-3p, thereby preventing ATG14 mRNA degradation. These actions contribute to enhanced autophagy and decreased chemosensitivity, correlating with poorer patient outcomes in gastric cancer treatment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn hepatocellular carcinoma, a related transcript, EIF3J-AS1, is found to be markedly upregulated relative to normal liver tissues. Its elevated levels are associated with tumor aggressiveness, including larger tumor size, vascular invasion, and advanced tumor stage. Functionally, EIF3J-AS1 acts as a competing endogenous RNA (ceRNA) by sequestering miR-122-5p, which in turn leads to the derepression of the target CTNND2. This axis enhances cell proliferation, migration, and invasion, and its expression also serves as a prognostic indicator of poor recurrence-free survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n \n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional evidence from studies in colorectal and esophageal cancers further supports an oncogenic role for EIF3J-AS1. In colorectal cancer, aberrant upregulation of EIF3J-AS1—mediated by enhanced H3K27 acetylation at its promoter—enables this lncRNA to sponge miR-3163, leading to increased expression of YAP1. This molecular event results in augmented cell proliferation and inhibited apoptosis. Similarly, in esophageal cancer, elevated EIF3J-AS1 expression is correlated with deeper invasion, lymph node metastasis, and poor overall survival. Here, EIF3J-AS1 functions by binding miR-373-3p, thereby facilitating the upregulation of AKT1 and promoting tumor growth and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n \n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yuhao Luo, Siting Zheng, Qianying Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA (lncRNA) "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "EIF3J-DT"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " induces chemoresistance of gastric cancer via autophagy activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15548627.2021.1901204"}], "href": "https://doi.org/10.1080/15548627.2021.1901204"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33764843"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33764843"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xue Yang, Bowen Yao, Yongshen Niu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia-induced lncRNA EIF3J-AS1 accelerates hepatocellular carcinoma progression via targeting miR-122-5p/CTNND2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.08.039"}], "href": "https://doi.org/10.1016/j.bbrc.2019.08.039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31421822"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31421822"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Dingsheng Liu, Hong Zhang, Jinchun Cong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "H3K27 acetylation-induced lncRNA EIF3J-AS1 improved proliferation and impeded apoptosis of colorectal cancer through miR-3163/YAP1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.29427"}], "href": "https://doi.org/10.1002/jcb.29427"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31709617"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31709617"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Wei-Tian Wei, Liang Wang, Jin-Xiao Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA EIF3J-AS1 enhanced esophageal cancer invasion via regulating AKT1 expression through sponging miR-373-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-020-70886-2"}], "href": "https://doi.org/10.1038/s41598-020-70886-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32811869"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32811869"}]}]}]}