EIF3L Gene

Name	eukaryotic translation initiation factor 3, subunit L
Description	Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in translational initiation and viral translational termination-reinitiation. Located in membrane. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The eukaryotic initiation factor 3 subunit L (EIF3L) is a nonessential but functionally significant component of the eIF3 complex that contributes to the fine‐tuning of translation initiation. Structural and biochemical studies in model systems have shown that EIF3L is incorporated as a subunit pair with EIF3K and is located on the “right side” of the complex. Its presence appears to modulate mRNA recruitment to the 40S pre‐initiation complex, such that knockdowns of the EIF3K/EIF3L pair lead to increased mRNA recruitment efficiency, indicating that EIF3L can function as a regulatory brake in translation initiation (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its role in canonical translation, EIF3L has been implicated in host–virus interactions. In studies of flaviviruses such as yellow fever virus, the viral nonstructural protein NS5 was shown to interact with EIF3L, and although overexpression of EIF3L had only a modest effect on viral replication, this interaction suggests that EIF3L is involved in regulating the balance of viral protein synthesis (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Similarly, in porcine epidemic diarrhea virus (PEDV) infection, experimental down‐regulation of EIF3L resulted in a significant increase in virus production, further supporting its role as a negative regulator of translation that can limit viral replication (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Recombinant expression and in silico structural analyses have revealed that EIF3L is predominantly α‐helical and engages in strong interactions with its partner subunit EIF3K, while also harboring multiple putative post‐translational modification sites that could be important for its regulation (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Furthermore, proteomic studies in the context of oncogene-induced senescence have identified altered ubiquitination of several translation initiation factors, including EIF3L, which supports an emerging view that post-translational modifications of components of the translation machinery can adjust protein synthesis in response to cellular stress (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings suggest that EIF3L plays a multifaceted role in the regulation of translation initiation by modulating mRNA recruitment, interacting with viral proteins to influence replication, and undergoing post-translational modifications that may adjust its activity during cellular stress responses.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "M Duane Smith, Yu Gu, Jordi Querol-Audí, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human-like eukaryotic translation initiation factor 3 from Neurospora crassa."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0078715"}], "href": "https://doi.org/10.1371/journal.pone.0078715"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24250809"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24250809"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Anna Herrmannová, Terezie Prilepskaja, Susan Wagner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Adapted formaldehyde gradient cross-linking protocol implicates human eIF3d and eIF3c, k and l subunits in the 43S and 48S pre-initiation complex assembly, respectively."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkz1185"}], "href": "https://doi.org/10.1093/nar/gkz1185"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31863585"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31863585"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ana Ts Morais, Ana Cb Terzian, Danilo Vb Duarte, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The eukaryotic translation initiation factor 3 subunit L protein interacts with Flavivirus NS5 and may modulate yellow fever virus replication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Virol J (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1743-422X-10-205"}], "href": "https://doi.org/10.1186/1743-422X-10-205"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23800076"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23800076"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ruiyang Wang, Ruisong Yu, Bingqing Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of host cell proteins that interact with the M protein of porcine epidemic diarrhea virus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Vet Microbiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.vetmic.2020.108729"}], "href": "https://doi.org/10.1016/j.vetmic.2020.108729"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32605758"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32605758"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ana T S Morais, Andreia N Meza, Gabriela C Araújo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Biophysical and structural characterization of the recombinant human eIF3L."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Protein Pept Lett (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/09298665113209990084"}], "href": "https://doi.org/10.2174/09298665113209990084"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23919378"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23919378"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Fee Bengsch, Zhigang Tu, Hsin-Yao Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive analysis of the ubiquitinome during oncogene-induced senescence in human fibroblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2015.1026492"}], "href": "https://doi.org/10.1080/15384101.2015.1026492"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25785348"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25785348"}]}]}]}
Synonyms	EIF3S6IP, HSPC021, EIF3S11, HSPC025, EIF3EIP, MSTP005
Proteins	EIF3L_HUMAN
NCBI Gene ID	51386
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

EIF3L has 8,389 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 113 datasets.

Click the + buttons to view associations for EIF3L from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

EIF3L Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of EIF3L gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of EIF3L gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of EIF3L gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of EIF3L gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of EIF3L gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of EIF3L gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of EIF3L gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of EIF3L gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of EIF3L gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of EIF3L gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of EIF3L gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of EIF3L gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with EIF3L protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with EIF3L gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of EIF3L gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of EIF3L gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of EIF3L gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of EIF3L gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing EIF3L protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing EIF3L protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing EIF3L protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with EIF3L protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with EIF3L protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing EIF3L protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of EIF3L gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with EIF3L gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with EIF3L gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with EIF3L gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by EIF3L gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with EIF3L gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with EIF3L gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with EIF3L gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with EIF3L gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at EIF3L gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of EIF3L gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of EIF3L gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing EIF3L from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with EIF3L gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of EIF3L gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with EIF3L gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.