{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ELFN1‐AS1 is a long noncoding RNA that emerges as a potent oncogenic regulator in a variety of human tumors. Its aberrant high expression is consistently linked to poor prognosis and advanced disease stages in cancers—including colorectal, esophageal, ovarian, non‐small cell lung, gastric, and pancreatic cancers. Mechanistically, ELFN1‐AS1 primarily functions as a competing endogenous RNA: it “sponges” multiple microRNAs (for example, miR‐4644, miR‐1205, miR‐183‐3p, miR‐497/miR‐497‐3p, and miR‐4270) to de‐repress target oncogenes such as TRIM44, MTA1, GFPT1, CCNE1, CLDN4, and SBK1. This ceRNA activity promotes tumor cell proliferation, migration, invasion, and resistance to apoptosis and chemotherapeutic agents. In addition, ELFN1‐AS1 can modulate epigenetic regulatory processes; for instance, by recruiting DNA methyltransferases to repress tumor suppressor genes (e.g., ZBTB16), thereby activating key signaling cascades such as the PI3K/AKT pathway. Moreover, its inclusion in various prognostic signatures—ranging from ferroptosis‐ and pyroptosis‐related models to immune‐related panels—underscores its multifaceted role in tumor progression and its potential as a diagnostic and therapeutic target. Evolutionary analyses further reveal that ELFN1‐AS1 is an evolutionarily novel transcript with predominant tumor‐restricted expression, which may contribute to its unique cancer‐promoting properties."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "22"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yimin Li, Yaqi Gan, Jiaxin Liu, et al. 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