{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ELMO1-AS1, a macrophage-associated long non-coding RNA, is significantly downregulated in hepatocellular carcinoma (HCC) tissues compared to adjacent non-tumorous tissues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " High expression levels of ELMO1-AS1 correlate with favorable treatment outcomes, suggesting its utility as an independent prognostic biomarker for HCC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Functional studies reveal that overexpression of ELMO1-AS1 in HCC cells suppresses cell proliferation, migration, and invasion, and it may exert these effects through targeting the gene ELMO1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Collectively, these findings indicate that ELMO1-AS1 could serve as a crucial regulator in HCC progression as well as a promising therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tao Luo, Miao Chen, Yuan Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Macrophage-associated lncRNA ELMO1-AS1: a novel therapeutic target and prognostic biomarker for hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S213833"}], "href": "https://doi.org/10.2147/OTT.S213833"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31498334"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31498334"}]}]}]}