ELOA Gene

Name elongin A
Description This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq, Jul 2008]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Elongin A (ELOA) is a multifunctional transcription factor that plays pivotal roles in both the regulation of RNA polymerase II elongation and in maintaining genomic integrity. In its canonical role, ELOA alleviates transient polymerase pausing to stimulate efficient transcript elongation and is prominently localized at active promoters and enhancers—with additional enrichment at nucleolar regions—thus fine‐tuning gene expression, including key stress‐responsive genes such as ATF3 and p21"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its role in transcription elongation, ELOA dynamically assembles into a ubiquitin ligase complex together with Elongin B/C and Cullin factors to target stalled RNA polymerase II for ubiquitination and proteasomal degradation following DNA damage or transcriptional stress."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": " Furthermore, its activity can be modulated by post‐translational modifications such as methylation by PRC2, which in turn helps repress a subset of lowly expressed target genes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n ELOA’s functional significance is also underscored by its involvement in developmental programs and cell cycle regulation. Its proper activity is critical for neuronal differentiation and megakaryocytic polyploidization, linking its transcriptional and ubiquitin ligase functions to broader aspects of cellular differentiation and tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, discrete domains within ELOA mediate interactions with cofactors such as ELOA‐binding protein 1 (ELOA‐BP1), which further modulate its dual activities as a transcription elongation enhancer and as the substrate recognition subunit of ubiquitin ligase complexes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Collectively, these findings underscore the versatile and context‐dependent functions of ELOA in orchestrating transcription elongation, regulating gene expression, and coupling these processes with protein turnover mechanisms in response to diverse cellular signals.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Junya Kawauchi, Makoto Inoue, Mizue Fukuda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional properties of mammalian elongin A and its role in stress response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.496703"}], "href": "https://doi.org/10.1074/jbc.M113.496703"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23828199"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23828199"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yating Wang, Liming Hou, M Behfar Ardehali, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elongin A regulates transcription in vivo through enhanced RNA polymerase processivity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA120.015876"}], "href": "https://doi.org/10.1074/jbc.RA120.015876"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33298525"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33298525"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "M Behfar Ardehali, Manashree Damle, Carlos Perea-Resa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elongin A associates with actively transcribed genes and modulates enhancer RNA levels with limited impact on transcription elongation rate in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA120.015877"}], "href": "https://doi.org/10.1074/jbc.RA120.015877"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33334895"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33334895"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Takashi Yasukawa, Takumi Kamura, Shigetaka Kitajima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2008.249"}], "href": "https://doi.org/10.1038/emboj.2008.249"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19037258"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19037258"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Juston C Weems, Brian D Slaughter, Jay R Unruh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cockayne syndrome B protein regulates recruitment of the Elongin A ubiquitin ligase to sites of DNA damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C117.777946"}], "href": "https://doi.org/10.1074/jbc.C117.777946"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28292928"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28292928"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Juston C Weems, Brian D Slaughter, Jay R Unruh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Assembly of the Elongin A Ubiquitin Ligase Is Regulated by Genotoxic and Other Stresses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.632794"}], "href": "https://doi.org/10.1074/jbc.M114.632794"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25878247"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25878247"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "M Behfar Ardehali, Anthony Anselmo, Jesse C Cochrane, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polycomb Repressive Complex 2 Methylates Elongin A to Regulate Transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2017.10.025"}], "href": "https://doi.org/10.1016/j.molcel.2017.10.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29153392"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29153392"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hiroshi Kanno, Hidemitsu Sato, Taka-Akira Yokoyama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The VHL tumor suppressor protein regulates tumorigenicity of U87-derived glioma stem-like cells by inhibiting the JAK/STAT signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2013.1773"}], "href": "https://doi.org/10.3892/ijo.2013.1773"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23338840"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23338840"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Katsuhisa Yamazaki, Teijiro Aso, Yoshinori Ohnishi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mammalian elongin A is not essential for cell viability but is required for proper cell cycle progression with limited alteration of gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C300047200"}], "href": "https://doi.org/10.1074/jbc.C300047200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12604609"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12604609"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Takashi Yasukawa, Shachi Bhatt, Tamotsu Takeuchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional elongation factor elongin A regulates retinoic acid-induced gene expression during neuronal differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2012.09.031"}], "href": "https://doi.org/10.1016/j.celrep.2012.09.031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23122963"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23122963"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Lanyue Hu, Weiwei Zhang, Zheng Xiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EloA promotes HEL polyploidization upon PMA stimulation through enhanced ERK1/2 activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Platelets (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/09537104.2021.1988548"}], "href": "https://doi.org/10.1080/09537104.2021.1988548"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34697988"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34697988"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Kenji Tamura, Keikichi Miyata, Kazunori Sugahara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0006-291x(03)01556-0"}], "href": "https://doi.org/10.1016/s0006-291x(03"}, {"type": "t", "text": "01556-0) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12943681"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12943681"}]}]}]}
NCBI Gene ID 6924
API
Download Associations
Predicted Functions View ELOA's ARCHS4 Predicted Functions.
Co-expressed Genes View ELOA's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View ELOA's ARCHS4 Predicted Functions.

Functional Associations

ELOA has 1,853 functional associations with biological entities spanning 6 categories (chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 40 datasets.

Click the + buttons to view associations for ELOA from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of ELOA gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
Carcinogenome Chemical Perturbation Carcinogenicity Signatures small molecule perturbations changing expression of ELOA gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
CCLE Cell Line Proteomics Cell lines associated with ELOA protein from the CCLE Cell Line Proteomics dataset.
CellMarker Gene-Cell Type Associations cell types associated with ELOA gene from the CellMarker Gene-Cell Type Associations dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of ELOA gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
CM4AI U2OS Cell Map Protein Localization Assemblies assemblies containing ELOA protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 cellular components containing ELOA protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 cellular components containing ELOA protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with ELOA protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
DepMap CRISPR Gene Dependency cell lines with fitness changed by ELOA gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with ELOA gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
DisGeNET Gene-Disease Associations diseases associated with ELOA gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
GO Biological Process Annotations 2023 biological processes involving ELOA gene from the curated GO Biological Process Annotations 2023 dataset.
GO Biological Process Annotations 2025 biological processes involving ELOA gene from the curated GO Biological Process Annotations2025 dataset.
GO Cellular Component Annotations 2023 cellular components containing ELOA protein from the curated GO Cellular Component Annotations 2023 dataset.
GO Cellular Component Annotations 2025 cellular components containing ELOA protein from the curated GO Cellular Component Annotations 2025 dataset.
GTEx eQTL 2025 SNPs regulating expression of ELOA gene from the GTEx eQTL 2025 dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of ELOA gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GTEx Tissue-Specific Aging Signatures tissue samples with high or low expression of ELOA gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset.
GWAS Catalog SNP-Phenotype Associations 2025 phenotypes associated with ELOA gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.
JASPAR Predicted Human Transcription Factor Targets 2025 transcription factors regulating expression of ELOA gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
JASPAR Predicted Mouse Transcription Factor Targets 2025 transcription factors regulating expression of ELOA gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures small molecule perturbations changing expression of ELOA gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures gene perturbations changing expression of ELOA gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
MoTrPAC Rat Endurance Exercise Training tissue samples with high or low expression of ELOA gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset.
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles drug perturbations changing expression of ELOA gene from the NIBR DRUG-seq U2OS MoA Box dataset.
PFOCR Pathway Figure Associations 2023 pathways involving ELOA protein from the PFOCR Pathway Figure Associations 2023 dataset.
PFOCR Pathway Figure Associations 2024 pathways involving ELOA protein from the Wikipathways PFOCR 2024 dataset.
Reactome Pathways 2024 pathways involving ELOA protein from the Reactome Pathways 2024 dataset.
Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of ELOA gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset.
Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of ELOA gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of ELOA gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of ELOA gene from the RummaGEO Gene Perturbation Signatures dataset.
Sanger Dependency Map Cancer Cell Line Proteomics cell lines associated with ELOA protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset.
Sci-Plex Drug Perturbation Signatures drug perturbations changing expression of ELOA gene from the Sci-Plex Drug Perturbation Signatures dataset.
Tahoe Therapeutics Tahoe 100M Perturbation Atlas drug perturbations changing expression of ELOA gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 tissues with high expression of ELOA protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of ELOA protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with ELOA protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.
WikiPathways Pathways 2024 pathways involving ELOA protein from the WikiPathways Pathways 2024 dataset.