{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ELOVL2‐AS1 has emerged as a functionally important long noncoding RNA in breast cancer. Recent studies have identified ELOVL2‐AS1 as a key enhancer RNA region whose expression is tightly linked to that of its target gene, ELOVL2, through direct chromatin interactions (1). In breast cancer, particularly in triple‐negative subtypes, both ELOVL2‐AS1 and ELOVL2 are expressed at significantly lower levels relative to luminal A subtypes. This reduction is associated with decreased expression of cilia‐related genes, suggesting that diminished ELOVL2‐AS1 levels may contribute to the loss of cilia characteristics and promote increased cell migration and metastatic potential. Functional assays have confirmed that overexpression of ELOVL2‐AS1 in triple‐negative breast cancer cells notably inhibits migration, implicating this lncRNA as a potential tumor suppressor. Furthermore, its inclusion in prognostic immune‐related lncRNA risk models underscores its value not only in reflecting tumor aggressiveness and patient outcome but also in potentially modulating the tumor microenvironment (2).\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n (1)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "   (2)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mingda Zhu, Jingyang Zhang, Guangyu Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ELOVL2-AS1 inhibits migration of triple negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.13264"}], "href": "https://doi.org/10.7717/peerj.13264"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35441059"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35441059"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ran Xiao, Meng Yang, Yuanyuan Tan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Five Immune-Related lncRNAs Predicting Survival and Tumor Microenvironment Characteristics in Breast Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Comput Math Methods Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/6676692"}], "href": "https://doi.org/10.1155/2021/6676692"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33727952"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33727952"}]}]}]}