{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNA ENTPD1‐AS1 has emerged from several independent studies as a multifaceted regulator in distinct disease contexts. In a genome‐scale functional screen for cell fate regulators, ENTPD1‐AS1 was identified as a candidate that confers robust resistance to anti‐FAS IgM–induced apoptosis in Jurkat T‐leukaemic cells, suggesting an important role in promoting cell survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, ENTPD1‐AS1 was found to be a component of a competing endogenous RNA (ceRNA) network in ulcerative colitis where its dysregulation is associated with altered interleukin signaling, neutrophil degranulation, adaptive immunity, and cell adhesion processes; these pathways are critical in mediating inflammation and disease progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, ENTPD1‐AS1 is a constituent of a prognostic six‐lncRNA signature in glioblastoma multiforme; here, its expression correlates with immune‐related biological processes that underpin tumorigenesis and clinical outcome, highlighting its potential as a biomarker for risk stratification."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Collectively, these findings indicate that ENTPD1‐AS1 plays a role in conferring apoptotic resistance and modulating immune responses, thereby contributing to disease progression in cancer and inflammatory disorders.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "D P Tonge, D Darling, F Farzaneh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Whole-genome-scale identification of novel non-protein-coding RNAs controlling cell proliferation and survival through a functional forward genetics strategy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-021-03983-5"}], "href": "https://doi.org/10.1038/s41598-021-03983-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34997014"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34997014"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jia-Wei Lu, Aimaier Rouzigu, Li-Hong Teng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Construction and Comprehensive Analysis of Inflammation-Related ceRNA Networks and Tissue-Infiltrating Immune Cells in Ulcerative Progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/6633442"}], "href": "https://doi.org/10.1155/2021/6633442"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34327234"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34327234"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Meng Zhou, Zhaoyue Zhang, Hengqiang Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An Immune-Related Six-lncRNA Signature to Improve Prognosis Prediction of Glioblastoma Multiforme."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Neurobiol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12035-017-0572-9"}], "href": "https://doi.org/10.1007/s12035-017-0572-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28527107"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28527107"}]}]}]}